Seroatlas · Human Serome Atlas

CCNL1

Cyclin-L1

Also known as: ania-6a, CCNL1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UK58
Gene
CCNL1
Ensembl
ENSG00000163660
Chromosome
3
Canonical length
526 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Involved in regulation of RNA splicing. Located in nucleus. Part of cyclin-dependent protein kinase holoenzyme complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

526 residues, UniProt reviewed canonical sequence.

>Q9UK58|CCNL1
     1  MASGPHSTAT AAAAASSAAP SAGGSSSGTT TTTTTTTGGI LIGDRLYSEV SLTIDHSLIP
    61  EERLSPTPSM QDGLDLPSET DLRILGCELI QAAGILLRLP QVAMATGQVL FHRFFYSKSF
   121  VKHSFEIVAM ACINLASKIE EAPRRIRDVI NVFHHLRQLR GKRTPSPLIL DQNYINTKNQ
   181  VIKAERRVLK ELGFCVHVKH PHKIIVMYLQ VLECERNQTL VQTAWNYMND SLRTNVFVRF
   241  QPETIACACI YLAARALQIP LPTRPHWFLL FGTTEEEIQE ICIETLRLYT RKKPNYELLE
   301  KEVEKRKVAL QEAKLKAKGL NPDGTPALST LGGFSPASKP SSPREVKAEE KSPISINVKT
   361  VKKEPEDRQQ ASKSPYNGVR KDSKRSRNSR SASRSRSRTR SRSRSHTPRR HYNNRRSRSG
   421  TYSSRSRSRS RSHSESPRRH HNHGSPHLKA KHTRDDLKSS NRHGHKRKKS RSRSQSKSRD
   481  HSDAAKKHRH ERGHHRDRRE RSRSFERSHK SKHHGGSRSG HGRHRR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCNL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
56 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 56 nTPM
  • bone marrow: 53 nTPM
  • liver: 48 nTPM
  • spleen: 40 nTPM
  • pancreas: 35 nTPM
  • ovary: 33 nTPM

Single-cell type

  • neutrophils: 1,427 nCPM
  • endometrial glandular cells: 874 nCPM
  • endometrial luminal cells: 865 nCPM
  • neutrophil progenitors: 609 nCPM
  • epididymal basal cells: 557 nCPM
  • salivary myoepithelial cells: 544 nCPM

Immune cell

  • neutrophil: 29 nTPM
  • NK-cell: 17 nTPM
  • naive CD4 T-cell: 17 nTPM
  • eosinophil: 16 nTPM
  • T-reg: 15 nTPM
  • naive B-cell: 15 nTPM

Brain region

  • medulla oblongata: 16 nTPM
  • cerebral cortex: 15 nTPM
  • white matter: 14 nTPM
  • cerebellum: 14 nTPM
  • hypothalamus: 12 nTPM
  • thalamus: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.26
gnomAD pLI
1
gnomAD missense Z
2.6
DepMap mean gene effect
-0.57
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCNL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCNL1 as an antibody target. Whether an autoantibody or antibody against CCNL1 could matter depends on whether native CCNL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCNL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCNL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCNL1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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