Seroatlas · Human Serome Atlas

EIF3J

Eukaryotic translation initiation factor 3 subunit J

Also known as: eIF3-alpha, eIF3-p35, EIF3J_HUMAN, EIF3S1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O75822
Gene
EIF3J
Ensembl
ENSG00000104131
Chromosome
15
Canonical length
258 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

This gene encodes a core subunit of the eukaryotic initiation factor 3 complex, which participates in the initiation of translation by aiding in the recruitment of protein and mRNA components to the 40S ribosome. There are pseudogenes for this gene on chromosomes 1, 3, and 9. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013]

Canonical amino-acid sequenceUniProt

258 residues, UniProt reviewed canonical sequence.

>O75822|EIF3J
     1  MAAAAAAAGD SDSWDADAFS VEDPVRKVGG GGTAGGDRWE GEDEDEDVKD NWDDDDDEKK
    61  EEAEVKPEVK ISEKKKIAEK IKEKERQQKK RQEEIKKRLE EPEEPKVLTP EEQLADKLRL
   121  KKLQEESDLE LAKETFGVNN AVYGIDAMNP SSRDDFTEFG KLLKDKITQY EKSLYYASFL
   181  EVLVRDVCIS LEIDDLKKIT NSLTVLCSEK QKQEKQSKAK KKKKGVVPGG GLKATMKDDL
   241  ADYGGYDGGY VQDYEDFM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EIF3J can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.6
Highest tissue expression
196 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 196 nTPM
  • tongue: 97 nTPM
  • pancreas: 62 nTPM
  • liver: 55 nTPM
  • salivary gland: 53 nTPM
  • spinal cord: 49 nTPM

Single-cell type

  • hepatocytes: 394 nCPM
  • esophageal apical cells: 344 nCPM
  • pancreatic acinar cells: 343 nCPM
  • syncytiotrophoblasts: 289 nCPM
  • oocytes: 286 nCPM
  • ocular epithelial cells: 270 nCPM

Immune cell

  • plasmacytoid DC: 77 nTPM
  • basophil: 64 nTPM
  • NK-cell: 61 nTPM
  • memory B-cell: 59 nTPM
  • naive B-cell: 54 nTPM
  • T-reg: 53 nTPM

Brain region

  • cerebral cortex: 64 nTPM
  • midbrain: 63 nTPM
  • pons: 59 nTPM
  • white matter: 59 nTPM
  • medulla oblongata: 56 nTPM
  • hypothalamus: 56 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.42
gnomAD pLI
0.86
gnomAD missense Z
1.21
DepMap mean gene effect
-0.58
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Eukaryotic translation initiation factor 3 subunit J
  • Eukaryotic translation initiation factor 3-like domain superfamily
  • Translation initiation factor eIF3 subunit

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EIF3J in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EIF3J as an antibody target. Whether an autoantibody or antibody against EIF3J could matter depends on whether native EIF3J is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EIF3J is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EIF3J as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EIF3J. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...