Seroatlas · Human Serome Atlas

ANP32B

Acidic leucine-rich nuclear phosphoprotein 32 family member B

Also known as: AN32B_HUMAN, APRIL, PHAPI2, SSP29

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q92688
Gene: ANP32B
Ensembl: ENSG00000136938
Chromosome: 9
Canonical length: 251 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Centrosome,Cytosol

OverviewNCBI Gene

Enables RNA polymerase binding activity and histone binding activity. Involved in several processes, including negative regulation of apoptotic process; nucleosome assembly; and positive regulation of protein export from nucleus. Located in cytoplasm; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

251 residues, UniProt reviewed canonical sequence.

>Q92688|ANP32B
     1  MDMKRRIHLE LRNRTPAAVR ELVLDNCKSN DGKIEGLTAE FVNLEFLSLI NVGLISVSNL
    61  PKLPKLKKLE LSENRIFGGL DMLAEKLPNL THLNLSGNKL KDISTLEPLK KLECLKSLDL
   121  FNCEVTNLND YRESVFKLLP QLTYLDGYDR EDQEAPDSDA EVDGVDEEEE DEEGEDEEDE
   181  DDEDGEEEEF DEEDDEDEDV EGDEDDDEVS EEEEEFGLDE EDEDEDEDEE EEEGGKGEKR
   241  KRETDDEGED D

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANP32B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 364 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 364 nTPM
bone marrow: 345 nTPM
thymus: 253 nTPM
tonsil: 233 nTPM
midbrain: 217 nTPM
lymph node: 208 nTPM

Single-cell type

megakaryocytes: 903 nCPM
megakaryocyte progenitors: 893 nCPM
erythrocyte progenitors: 855 nCPM
monocyte progenitors: 700 nCPM
extravillous trophoblasts: 616 nCPM
platelets: 596 nCPM

Immune cell

T-reg: 163 nTPM
non-classical monocyte: 151 nTPM
naive CD4 T-cell: 144 nTPM
memory CD4 T-cell: 123 nTPM
eosinophil: 119 nTPM
naive CD8 T-cell: 112 nTPM

Brain region

medulla oblongata: 209 nTPM
white matter: 206 nTPM
spinal cord: 176 nTPM
basal ganglia: 172 nTPM
midbrain: 160 nTPM
hypothalamus: 159 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.33
gnomAD pLI: 0.96
gnomAD missense Z: 1.27
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ANP32B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANP32B as an antibody target. Whether an autoantibody or antibody against ANP32B could matter depends on whether native ANP32B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANP32B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANP32B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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