Seroatlas · Human Serome Atlas

EFCAB14

EF-hand calcium-binding domain-containing protein 14

Also known as: EFC14_HUMAN, KIAA0494

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75071
Gene: EFCAB14
Ensembl: ENSG00000159658
Chromosome: 1
Canonical length: 495 aa
Protein class: Predicted membrane proteins
Subcellular location: Nucleoli,Golgi apparatus,Cytosol

OverviewNCBI Gene

Predicted to enable calcium ion binding activity. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

495 residues, UniProt reviewed canonical sequence.

>O75071|EFCAB14
     1  MKKRKELNAL IGLAGDSRRK KPKKGPSSHR LLRTEPPDSD SESSSEEEEE FGVVGNRSRF
    61  AKGDYLRCCK ICYPLCGFVI LAACVVACVG LVWMQVALKE DLDALKEKFR TMESNQKSSF
   121  QEIPKLNEEL LSKQKQLEKI ESGEMGLNKV WINITEMNKQ ISLLTSAVNH LKANVKSAAD
   181  LISLPTTVEG LQKSVASIGN TLNSVHLAVE ALQKTVDEHK KTMELLQSDM NQHFLKETPG
   241  SNQIIPSPSA TSELDNKTHS ENLKQDILYL HNSLEEVNSA LVGYQRQNDL KLEGMNETVS
   301  NLTQRVNLIE SDVVAMSKVE KKANLSFSMM GDRSATLKRQ SLDQVTNRTD TVKIQSIKKE
   361  DSSNSQVSKL REKLQLISAL TNKPESNRPP ETADEEQVES FTSKPSALPK FSQFLGDPVE
   421  KAAQLRPISL PGVSSTEDLQ DLFRKTGQDV DGKLTYQEIW TSLGSAMPEP ESLRAFDSDG
   481  DGRYSFLELR VALGI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EFCAB14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 150 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 150 nTPM
stomach: 62 nTPM
adipose tissue: 47 nTPM
tongue: 43 nTPM
kidney: 41 nTPM
thyroid gland: 41 nTPM

Single-cell type

esophageal apical cells: 501 nCPM
foveolar cells: 241 nCPM
urothelial cells: 223 nCPM
parietal cells: 193 nCPM
prostatic hillock cells: 159 nCPM
prostatic club cells: 157 nCPM

Immune cell

eosinophil: 37 nTPM
MAIT T-cell: 34 nTPM
intermediate monocyte: 28 nTPM
non-classical monocyte: 26 nTPM
gdT-cell: 25 nTPM
total PBMC: 24 nTPM

Brain region

medulla oblongata: 81 nTPM
white matter: 80 nTPM
basal ganglia: 76 nTPM
midbrain: 73 nTPM
cerebellum: 69 nTPM
spinal cord: 66 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.96
gnomAD pLI: 0
gnomAD missense Z: 0.39
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

calcium ion binding

Protein domainsUniProt · Pfam · InterPro

EF-hand domain
EF-hand domain pair
EF-hand calcium-binding domain-containing protein 14

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EFCAB14 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EFCAB14 as an antibody target. Whether an autoantibody or antibody against EFCAB14 could matter depends on whether native EFCAB14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EFCAB14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EFCAB14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...