Seroatlas · Human Serome Atlas

HIRIP3

HIRA-interacting protein 3

Also known as: HIRP3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BW71
Gene: HIRIP3
Ensembl: ENSG00000149929
Chromosome: 16
Canonical length: 556 aa
Protein class: Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

The HIRA protein shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae. The structural features of the HIRA protein suggest that it may function as part of a multiprotein complex. Several cDNAs encoding HIRA-interacting proteins, or HIRIPs, have been identified. In vitro, the protein encoded by this gene binds HIRA, as well as H2B and H3 core histones, indicating that a complex containing HIRA-HIRIP3 could function in some aspects of chromatin and histone metabolism. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

556 residues, UniProt reviewed canonical sequence.

>Q9BW71|HIRIP3
     1  MAREKEMQEF TRSFFRGRPD LSTLTHSIVR RRYLAHSGRS HLEPEEKQAL KRLVEEELLK
    61  MQVDEAASRE DKLDLTKKGK RPPTPCSDPE RKRFRFNSES ESGSEASSPD YFGPPAKNGV
   121  AAEVSPAKEE NPRRASKAVE ESSDEERQRD LPAQRGEESS EEEEKGYKGK TRKKPVVKKQ
   181  APGKASVSRK QAREESEESE AEPVQRTAKK VEGNKGTKSL KESEQESEEE ILAQKKEQRE
   241  EEVEEEEKEE DEEKGDWKPR TRSNGRRKSA REERSCKQKS QAKRLLGDSD SEEEQKEAAS
   301  SGDDSGRDRE PPVQRKSEDR TQLKGGKRLS GSSEDEEDSG KGEPTAKGSR KMARLGSTSG
   361  EESDLEREVS DSEAGGGPQG ERKNRSSKKS SRKGRTRSSS SSSDGSPEAK GGKAGSGRRG
   421  EDHPAVMRLK RYIRACGAHR NYKKLLGSCC SHKERLSILR AELEALGMKG TPSLGKCRAL
   481  KEQREEAAEV ASLDVANIIS GSGRPRRRTA WNPLGEAAPP GELYRRTLDS DEERPRPAPP
   541  DWSHMRGIIS SDGESN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HIRIP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 39 nTPM

Expression across tissuesHPA

Tissue

testis: 39 nTPM
skeletal muscle: 31 nTPM
spinal cord: 29 nTPM
midbrain: 24 nTPM
thymus: 24 nTPM
cerebellum: 23 nTPM

Single-cell type

late primary spermatocytes: 161 nCPM
early primary spermatocytes: 85 nCPM
megakaryocyte progenitors: 66 nCPM
oocytes: 55 nCPM
differentiating spermatogonia: 50 nCPM
monocyte progenitors: 49 nCPM

Immune cell

T-reg: 23 nTPM
non-classical monocyte: 21 nTPM
naive CD4 T-cell: 19 nTPM
memory B-cell: 19 nTPM
plasmacytoid DC: 19 nTPM
memory CD4 T-cell: 19 nTPM

Brain region

medulla oblongata: 19 nTPM
white matter: 19 nTPM
basal ganglia: 19 nTPM
midbrain: 17 nTPM
thalamus: 17 nTPM
amygdala: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.87
gnomAD pLI: 0
gnomAD missense Z: -0.82
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

chromatin organization

Molecular functions

H2A-H2B histone complex chaperone activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Histone chaperone domain CHZ
HIRA-interacting protein 3
Histone chaperone domain CHZ

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HIRIP3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HIRIP3 as an antibody target. Whether an autoantibody or antibody against HIRIP3 could matter depends on whether native HIRIP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HIRIP3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HIRIP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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