Seroatlas · Human Serome Atlas

EIF2S2

Eukaryotic translation initiation factor 2 subunit 2

Also known as: EIF2, EIF2beta, IF2B_HUMAN, PPP1R67

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P20042
Gene
EIF2S2
Ensembl
ENSG00000125977
Chromosome
20
Canonical length
333 aa
Protein class
Cancer-related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Endoplasmic reticulum,Cytosol

OverviewNCBI Gene

Eukaryotic translation initiation factor 2 (EIF-2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. EIF-2 is composed of three subunits, alpha, beta, and gamma, with the protein encoded by this gene representing the beta subunit. The beta subunit catalyzes the exchange of GDP for GTP, which recycles the EIF-2 complex for another round of initiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

Canonical amino-acid sequenceUniProt

333 residues, UniProt reviewed canonical sequence.

>P20042|EIF2S2
     1  MSGDEMIFDP TMSKKKKKKK KPFMLDEEGD TQTEETQPSE TKEVEPEPTE DKDLEADEED
    61  TRKKDASDDL DDLNFFNQKK KKKKTKKIFD IDEAEEGVKD LKIESDVQEP TEPEDDLDIM
   121  LGNKKKKKKN VKFPDEDEIL EKDEALEDED NKKDDGISFS NQTGPAWAGS ERDYTYEELL
   181  NRVFNIMREK NPDMVAGEKR KFVMKPPQVV RVGTKKTSFV NFTDICKLLH RQPKHLLAFL
   241  LAELGTSGSI DGNNQLVIKG RFQQKQIENV LRRYIKEYVT CHTCRSPDTI LQKDTRLYFL
   301  QCETCHSRCS VASIKTGFQA VTGKRAQLRA KAN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EIF2S2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
101 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 101 nTPM
  • pancreas: 77 nTPM
  • esophagus: 61 nTPM
  • tongue: 60 nTPM
  • urinary bladder: 59 nTPM
  • liver: 55 nTPM

Single-cell type

  • syncytiotrophoblasts: 691 nCPM
  • esophageal apical cells: 683 nCPM
  • hepatocytes: 460 nCPM
  • extravillous trophoblasts: 418 nCPM
  • migrating cytotrophoblasts: 403 nCPM
  • gastric chief cells: 389 nCPM

Immune cell

  • plasmacytoid DC: 106 nTPM
  • T-reg: 96 nTPM
  • intermediate monocyte: 89 nTPM
  • memory B-cell: 85 nTPM
  • non-classical monocyte: 84 nTPM
  • memory CD4 T-cell: 77 nTPM

Brain region

  • white matter: 44 nTPM
  • medulla oblongata: 38 nTPM
  • spinal cord: 36 nTPM
  • cerebellum: 35 nTPM
  • pons: 34 nTPM
  • hypothalamus: 32 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.34
gnomAD pLI
0.95
gnomAD missense Z
2.9
DepMap mean gene effect
-1.36
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 14% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EIF2S2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EIF2S2 as an antibody target. Whether an autoantibody or antibody against EIF2S2 could matter depends on whether native EIF2S2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EIF2S2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EIF2S2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EIF2S2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...