SNAI1
Zinc finger protein SNAI1
Also known as: SLUGH2, SNA, SNAH, SNAI1_HUMAN, SNAIL, SNAIL1
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O95863
- Gene
- SNAI1
- Ensembl
- ENSG00000124216
- Chromosome
- 20
- Canonical length
- 264 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo. At least two variants of a similar processed pseudogene have been found on chromosome 2. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
264 residues, UniProt reviewed canonical sequence.
>O95863|SNAI1
1 MPRSFLVRKP SDPNRKPNYS ELQDSNPEFT FQQPYDQAHL LAAIPPPEIL NPTASLPMLI
61 WDSVLAPQAQ PIAWASLRLQ ESPRVAELTS LSDEDSGKGS QPPSPPSPAP SSFSSTSVSS
121 LEAEAYAAFP GLGQVPKQLA QLSEAKDLQA RKAFNCKYCN KEYLSLGALK MHIRSHTLPC
181 VCGTCGKAFS RPWLLQGHVR THTGEKPFSC PHCSRAFADR SNLRAHLQTH SDVKKYQCQA
241 CARTFSRMSL LHKHQESGCS GCPRLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SNAI1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.57
- Highest tissue expression
- 29 nTPM
Expression across tissuesHPA
Tissue
- adipose tissue: 29 nTPM
- blood vessel: 17 nTPM
- breast: 16 nTPM
- lung: 16 nTPM
- heart muscle: 16 nTPM
- gallbladder: 15 nTPM
Single-cell type
- extravillous trophoblasts: 116 nCPM
- breast lactating cells: 61 nCPM
- pdcs: 55 nCPM
- vascular endothelial cells: 49 nCPM
- tuft cells: 46 nCPM
- hepatic stellate cells: 45 nCPM
Immune cell
- plasmacytoid DC: 1.2 nTPM
- myeloid DC: 0.3 nTPM
- classical monocyte: 0.2 nTPM
- basophil: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
Brain region
- medulla oblongata: 6.7 nTPM
- thalamus: 6.5 nTPM
- hypothalamus: 5.6 nTPM
- white matter: 3.6 nTPM
- cerebral cortex: 3.5 nTPM
- midbrain: 3.2 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.68
- gnomAD pLI
- 0.22
- gnomAD missense Z
- 1.31
- DepMap mean gene effect
- 0.06
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- aortic valve morphogenesis
- canonical Wnt signaling pathway
- cartilage morphogenesis
- epithelial cell migration
- epithelial to mesenchymal transition
- epithelial to mesenchymal transition involved in endocardial cushion formation
- hair follicle morphogenesis
- heterochromatin organization
- left/right pattern formation
- mesoderm formation
- negative regulation of cell differentiation involved in embryonic placenta development
- negative regulation of DNA damage response, signal transduction by p53 class mediator
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
- negative regulation of transcription by RNA polymerase II
- negative regulation of vitamin D biosynthetic process
- Notch signaling pathway
- osteoblast differentiation
- positive regulation of cell migration
- positive regulation of DNA-templated transcription
- positive regulation of epithelial to mesenchymal transition
- regulation of bicellular tight junction assembly
- regulation of DNA-templated transcription
- roof of mouth development
- trophoblast giant cell differentiation
Molecular functions
- DNA-binding transcription repressor activity, RNA polymerase II-specific
- E-box binding
- kinase binding
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding
- sequence-specific double-stranded DNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of SNAI1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SNAI1 as an antibody target. Whether an autoantibody or antibody against SNAI1 could matter depends on whether native SNAI1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SNAI1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SNAI1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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