Seroatlas · Human Serome Atlas

MARCKS

Myristoylated alanine-rich C-kinase substrate

Also known as: 80K-L, MACS, MARCS_HUMAN, PKCSL

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P29966
Gene
MARCKS
Ensembl
ENSG00000277443
Chromosome
6
Canonical length
332 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Endoplasmic reticulum,Plasma membrane,Cell Junctions,Primary cilium,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

332 residues, UniProt reviewed canonical sequence.

>P29966|MARCKS
     1  MGAQFSKTAA KGEAAAERPG EAAVASSPSK ANGQENGHVK VNGDASPAAA ESGAKEELQA
    61  NGSAPAADKE EPAAAGSGAA SPSAAEKGEP AAAAAPEAGA SPVEKEAPAE GEAAEPGSPT
   121  AAEGEAASAA SSTSSPKAED GATPSPSNET PKKKKKRFSF KKSFKLSGFS FKKNKKEAGE
   181  GGEAEAPAAE GGKDEAAGGA AAAAAEAGAA SGEQAAAPGE EAAAGEEGAA GGDPQEAKPQ
   241  EAAVAPEKPP ASDETKAAEE PSKVEEKKAE EAGASAAACE APSAAGPGAP PEQEAAPAEE
   301  PAAAAASSAC AAPSQEAQPE CSPEAPPAEA AE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MARCKS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.74
Highest tissue expression
119 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 119 nTPM
  • bone marrow: 99 nTPM
  • urinary bladder: 81 nTPM
  • cerebellum: 74 nTPM
  • colon: 71 nTPM
  • amygdala: 67 nTPM

Single-cell type

  • neutrophils: 1,059 nCPM
  • urothelial cells: 965 nCPM
  • esophageal apical cells: 932 nCPM
  • pancreatic acinar cells: 578 nCPM
  • colonocytes: 514 nCPM
  • suprabasal keratinocytes: 469 nCPM

Immune cell

  • neutrophil: 19 nTPM
  • intermediate monocyte: 13 nTPM
  • non-classical monocyte: 7.5 nTPM
  • memory B-cell: 4.6 nTPM
  • classical monocyte: 3.9 nTPM
  • naive B-cell: 1.9 nTPM

Brain region

  • spinal cord: 225 nTPM
  • white matter: 217 nTPM
  • hypothalamus: 186 nTPM
  • midbrain: 186 nTPM
  • medulla oblongata: 170 nTPM
  • thalamus: 153 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.1
gnomAD pLI
0.33
gnomAD missense Z
0.29
DepMap mean gene effect
-0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MARCKS in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MARCKS as an antibody target. Whether an autoantibody or antibody against MARCKS could matter depends on whether native MARCKS is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MARCKS is annotated at the cell surface, where native MARCKS is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MARCKS as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MARCKS. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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