Seroatlas · Human Serome Atlas

CD151

CD151 antigen

Also known as: CD151_HUMAN, PETA-3, RAPH, SFA-1, TSPAN24

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P48509
Gene
CD151
Ensembl
ENSG00000177697
Chromosome
11
Canonical length
253 aa
Protein class
Blood group antigen proteins, CD markers, Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters

OverviewNCBI Gene

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

253 residues, UniProt reviewed canonical sequence.

>P48509|CD151
     1  MGEFNEKKTT CGTVCLKYLL FTYNCCFWLA GLAVMAVGIW TLALKSDYIS LLASGTYLAT
    61  AYILVVAGTV VMVTGVLGCC ATFKERRNLL RLYFILLLII FLLEIIAGIL AYAYYQQLNT
   121  ELKENLKDTM TKRYHQPGHE AVTSAVDQLQ QEFHCCGSNN SQDWRDSEWI RSQEAGGRVV
   181  PDSCCKTVVA LCGQRDHASN IYKVEGGCIT KLETFIQEHL RVIGAVGIGI ACVQVFGMIF
   241  TCCLYRSLKL EHY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CD151 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
806 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 806 nTPM
  • heart muscle: 323 nTPM
  • adipose tissue: 308 nTPM
  • breast: 260 nTPM
  • pancreas: 258 nTPM
  • smooth muscle: 238 nTPM

Single-cell type

  • decidual stromal cells: 670 nCPM
  • alveolar cells type 1: 612 nCPM
  • platelets: 594 nCPM
  • extravillous trophoblasts: 570 nCPM
  • breast myoepithelial cells: 467 nCPM
  • epididymal principal cells: 443 nCPM

Immune cell

  • non-classical monocyte: 24 nTPM
  • basophil: 24 nTPM
  • intermediate monocyte: 19 nTPM
  • classical monocyte: 19 nTPM
  • eosinophil: 15 nTPM
  • myeloid DC: 12 nTPM

Brain region

  • hypothalamus: 68 nTPM
  • choroid plexus: 68 nTPM
  • medulla oblongata: 65 nTPM
  • pons: 57 nTPM
  • thalamus: 53 nTPM
  • spinal cord: 53 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CD151.

Disease | AllUniProt

Conditions CD151 is implicated in, by any mechanism.

  • Epidermolysis bullosa simplex 7, with nephropathy and deafness (EBS7) MIM:609057

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 242 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Epidermolysis bullosa simplex 7, with nephropathy and deafness
  • RAPH BLOOD GROUP SYSTEM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.09
gnomAD pLI
0
gnomAD missense Z
0.59
DepMap mean gene effect
-0.16
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CD151 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CD151 as an antibody target. Whether an autoantibody or antibody against CD151 could matter depends on whether native CD151 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CD151 is annotated at the cell surface, where native CD151 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CD151 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CD151. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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