Seroatlas · Human Serome Atlas

CALM1

Calmodulin-1

Also known as: CALM1_HUMAN, CALML2, CAMI, DD132, PHKD, PHKD1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0DP23
Gene
CALM1
Ensembl
ENSG00000198668
Chromosome
14
Canonical length
149 aa
Protein class
Disease related genes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, RAS pathway related proteins
Subcellular location
Cytosol
Quaternary structure
Homotetramer

OverviewNCBI Gene

This gene encodes one of three calmodulin proteins which are members of the EF-hand calcium-binding protein family. Calcium-induced activation of calmodulin regulates and modulates the function of cardiac ion channels. Two pseudogenes have been identified on chromosome 7 and X. Multiple transcript variants encoding different isoforms have been found for this gene.A missense mutation in the CALM1 gene has been associated with ventricular tachycardia.[provided by RefSeq, May 2020]

Canonical amino-acid sequenceUniProt

149 residues, UniProt reviewed canonical sequence.

>P0DP23|CALM1
     1  MADQLTEEQI AEFKEAFSLF DKDGDGTITT KELGTVMRSL GQNPTEAELQ DMINEVDADG
    61  NGTIDFPEFL TMMARKMKDT DSEEEIREAF RVFDKDGNGY ISAAELRHVM TNLGEKLTDE
   121  EVDEMIREAD IDGDGQVNYE EFVQMMTAK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CALM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
837 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 837 nTPM
  • hippocampal formation: 685 nTPM
  • cerebellum: 676 nTPM
  • basal ganglia: 673 nTPM
  • amygdala: 661 nTPM
  • skeletal muscle: 559 nTPM

Single-cell type

  • esophageal apical cells: 6,885 nCPM
  • respiratory ciliated cells: 2,827 nCPM
  • fallopian tube ciliated cells: 2,059 nCPM
  • platelets: 1,762 nCPM
  • esophageal suprabasal cells: 1,746 nCPM
  • syncytiotrophoblasts: 1,650 nCPM

Immune cell

  • total PBMC: 1,226 nTPM
  • basophil: 1,106 nTPM
  • MAIT T-cell: 1,037 nTPM
  • T-reg: 974 nTPM
  • memory CD8 T-cell: 930 nTPM
  • memory CD4 T-cell: 887 nTPM

Brain region

  • cerebral cortex: 1,865 nTPM
  • hippocampal formation: 1,468 nTPM
  • basal ganglia: 1,239 nTPM
  • white matter: 1,201 nTPM
  • pons: 1,086 nTPM
  • thalamus: 1,050 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CALM1.

Disease | AllUniProt

Conditions CALM1 is implicated in, by any mechanism.

  • Ventricular tachycardia, catecholaminergic polymorphic, 4 (CPVT4) MIM:614916
  • Long QT syndrome 14 (LQT14) MIM:616247

Disease | GeneticClinVar

20 pathogenic / likely-pathogenic of 198 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.33
gnomAD pLI
0.94
gnomAD missense Z
3.05
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CALM1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CALM1 as an antibody target. Whether an autoantibody or antibody against CALM1 could matter depends on whether native CALM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CALM1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CALM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CALM1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...