Seroatlas · Human Serome Atlas

ARHGAP33

Rho GTPase-activating protein 33

Also known as: FLJ39019, RHG33_HUMAN, SNX26, TCGAP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O14559
Gene
ARHGAP33
Ensembl
ENSG00000004777
Chromosome
19
Canonical length
1287 aa
Protein class
Predicted intracellular proteins
Subcellular location
Plasma membrane,Actin filaments,Cytosol

OverviewNCBI Gene

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Alternative splice variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010]

Canonical amino-acid sequenceUniProt

1287 residues, UniProt reviewed canonical sequence.

>O14559|ARHGAP33
     1  MVARSTDSLD GPGEGSVQPL PTAGGPSVKG KPGKRLSAPR GPFPRLADCA HFHYENVDFG
    61  HIQLLLSPDR EGPSLSGENE LVFGVQVTCQ GRSWPVLRSY DDFRSLDAHL HRCIFDRRFS
   121  CLPELPPPPE GARAAQMLVP LLLQYLETLS GLVDSNLNCG PVLTWMELDN HGRRLLLSEE
   181  ASLNIPAVAA AHVIKRYTAQ APDELSFEVG DIVSVIDMPP TEDRSWWRGK RGFQVGFFPS
   241  ECVELFTERP GPGLKADADG PPCGIPAPQG ISSLTSAVPR PRGKLAGLLR TFMRSRPSRQ
   301  RLRQRGILRQ RVFGCDLGEH LSNSGQDVPQ VLRCCSEFIE AHGVVDGIYR LSGVSSNIQR
   361  LRHEFDSERI PELSGPAFLQ DIHSVSSLCK LYFRELPNPL LTYQLYGKFS EAMSVPGEEE
   421  RLVRVHDVIQ QLPPPHYRTL EYLLRHLARM ARHSANTSMH ARNLAIVWAP NLLRSMELES
   481  VGMGGAAAFR EVRVQSVVVE FLLTHVDVLF SDTFTSAGLD PAGRCLLPRP KSLAGSCPST
   541  RLLTLEEAQA RTQGRLGTPT EPTTPKAPAS PAERRKGERG EKQRKPGGSS WKTFFALGRG
   601  PSVPRKKPLP WLGGTRAPPQ PSGSRPDTVT LRSAKSEESL SSQASGAGLQ RLHRLRRPHS
   661  SSDAFPVGPA PAGSCESLSS SSSSESSSSE SSSSSSESSA AGLGALSGSP SHRTSAWLDD
   721  GDELDFSPPR CLEGLRGLDF DPLTFRCSSP TPGDPAPPAS PAPPAPASAF PPRVTPQAIS
   781  PRGPTSPASP AALDISEPLA VSVPPAVLEL LGAGGAPASA TPTPALSPGR SLRPHLIPLL
   841  LRGAEAPLTD ACQQEMCSKL RGAQGPLGPD MESPLPPPPL SLLRPGGAPP PPPKNPARLM
   901  ALALAERAQQ VAEQQSQQEC GGTPPASQSP FHRSLSLEVG GEPLGTSGSG PPPNSLAHPG
   961  AWVPGPPPYL PRQQSDGSLL RSQRPMGTSR RGLRGPAQVS AQLRAGGGGR DAPEAAAQSP
  1021  CSVPSQVPTP GFFSPAPREC LPPFLGVPKP GLYPLGPPSF QPSSPAPVWR SSLGPPAPLD
  1081  RGENLYYEIG ASEGSPYSGP TRSWSPFRSM PPDRLNASYG MLGQSPPLHR SPDFLLSYPP
  1141  APSCFPPDHL GYSAPQHPAR RPTPPEPLYV NLALGPRGPS PASSSSSSPP AHPRSRSDPG
  1201  PPVPRLPQKQ RAPWGPRTPH RVPGPWGPPE PLLLYRAAPP AYGRGGELHR GSLYRNGGQR
  1261  GEGAGPPPPY PTPSWSLHSE GQTRSYC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARHGAP33 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
39 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 39 nTPM
  • basal ganglia: 35 nTPM
  • cerebellum: 33 nTPM
  • testis: 33 nTPM
  • spinal cord: 32 nTPM
  • pituitary gland: 29 nTPM

Single-cell type

  • oligodendrocytes: 32 nCPM
  • oligodendrocyte progenitor cells: 28 nCPM
  • brain inhibitory neurons: 26 nCPM
  • other brain neurons: 25 nCPM
  • early primary spermatocytes: 23 nCPM
  • retinal bipolar cells: 21 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 49 nTPM
  • basal ganglia: 41 nTPM
  • amygdala: 38 nTPM
  • white matter: 35 nTPM
  • hippocampal formation: 32 nTPM
  • hypothalamus: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.41
gnomAD pLI
0.03
gnomAD missense Z
1.8
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARHGAP33 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARHGAP33 as an antibody target. Whether an autoantibody or antibody against ARHGAP33 could matter depends on whether native ARHGAP33 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARHGAP33 is annotated at the cell surface, where native ARHGAP33 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ARHGAP33 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ARHGAP33. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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