Seroatlas · Human Serome Atlas

ITGB1BP1

Integrin beta-1-binding protein 1

Also known as: ICAP-1A, ICAP-1alpha, ICAP-1B, ICAP1, ICAP1A, ICAP1B, ITBP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O14713
Gene
ITGB1BP1
Ensembl
ENSG00000119185
Chromosome
2
Canonical length
200 aa
Protein class
Predicted intracellular proteins, Transporters
Subcellular location
Nucleoplasm,Nuclear bodies,Cytosol

OverviewNCBI Gene

The cytoplasmic domains of integrins are essential for cell adhesion. The protein encoded by this gene binds to the beta1 integrin cytoplasmic domain. The interaction between this protein and beta1 integrin is highly specific. Two isoforms of this protein are derived from alternatively spliced transcripts. The shorter form of this protein does not interact with the beta1 integrin cytoplasmic domain. The longer form is a phosphoprotein and the extent of its phosphorylation is regulated by the cell-matrix interaction, suggesting an important role of this protein during integrin-dependent cell adhesion. Several transcript variants, some protein-coding and some non-protein coding, have been found for this gene. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

200 residues, UniProt reviewed canonical sequence.

>O14713|ITGB1BP1
     1  MFRKGKKRHS SSSSQSSEIS TKSKSVDSSL GGLSRSSTVA SLDTDSTKSS GQSNNNSDTC
    61  AEFRIKYVGA IEKLKLSEGK GLEGPLDLIN YIDVAQQDGK LPFVPPEEEF IMGVSKYGIK
   121  VSTSDQYDVL HRHALYLIIR MVCYDDGLGA GKSLLALKTT DASNEEYSLW VYQCNSLEQA
   181  QAICKVLSTA FDSVLTSEKP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ITGB1BP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
107 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 107 nTPM
  • breast: 57 nTPM
  • kidney: 50 nTPM
  • basal ganglia: 49 nTPM
  • cerebral cortex: 44 nTPM
  • choroid plexus: 44 nTPM

Single-cell type

  • megakaryocytes: 167 nCPM
  • adipocytes: 162 nCPM
  • decidual stromal cells: 158 nCPM
  • hepatic stellate cells: 149 nCPM
  • melanocytes: 139 nCPM
  • fibro-adipogenic progenitors: 137 nCPM

Immune cell

  • basophil: 87 nTPM
  • T-reg: 62 nTPM
  • myeloid DC: 57 nTPM
  • eosinophil: 56 nTPM
  • gdT-cell: 55 nTPM
  • intermediate monocyte: 54 nTPM

Brain region

  • basal ganglia: 93 nTPM
  • cerebral cortex: 79 nTPM
  • thalamus: 75 nTPM
  • white matter: 70 nTPM
  • cerebellum: 67 nTPM
  • pons: 66 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.14
gnomAD pLI
0
gnomAD missense Z
0.71
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • PTB/PI domain
  • Integrin binding protein, ICAP-1
  • Beta-1 integrin binding protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ITGB1BP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ITGB1BP1 as an antibody target. Whether an autoantibody or antibody against ITGB1BP1 could matter depends on whether native ITGB1BP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ITGB1BP1 is annotated at the cell surface, where native ITGB1BP1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ITGB1BP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ITGB1BP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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