Seroatlas · Human Serome Atlas

CDC42SE1

CDC42 small effector protein 1

Also known as: C42S1_HUMAN, SCIP1, SPEC1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NRR8
Gene
CDC42SE1
Ensembl
ENSG00000197622
Chromosome
1
Canonical length
79 aa
Protein class
Predicted intracellular proteins
Subcellular location
Cell Junctions

OverviewNCBI Gene

Predicted to enable GTPase inhibitor activity. Predicted to be involved in signal transduction. Located in cell junction. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

79 residues, UniProt reviewed canonical sequence.

>Q9NRR8|CDC42SE1
     1  MSEFWHKLGC CVVEKPQPKK KRRRIDRTMI GEPMNFVHLT HIGSGEMGAG DGLAMTGAVQ
    61  EQMRSKGNRD RPWSNSRGL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDC42SE1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.63
Highest tissue expression
120 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 120 nTPM
  • esophagus: 97 nTPM
  • tonsil: 79 nTPM
  • lymph node: 79 nTPM
  • bone marrow: 77 nTPM
  • lung: 71 nTPM

Single-cell type

  • neutrophils: 680 nCPM
  • esophageal apical cells: 586 nCPM
  • nk-cells: 268 nCPM
  • innate lymphoid cells: 210 nCPM
  • esophageal suprabasal cells: 199 nCPM
  • epicardial cells: 173 nCPM

Immune cell

  • neutrophil: 371 nTPM
  • eosinophil: 229 nTPM
  • basophil: 125 nTPM
  • T-reg: 123 nTPM
  • NK-cell: 91 nTPM
  • gdT-cell: 89 nTPM

Brain region

  • white matter: 32 nTPM
  • medulla oblongata: 30 nTPM
  • thalamus: 30 nTPM
  • spinal cord: 30 nTPM
  • pons: 29 nTPM
  • midbrain: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.63
gnomAD pLI
0
gnomAD missense Z
1.01
DepMap mean gene effect
-0.31
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CDC42SE1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDC42SE1 as an antibody target. Whether an autoantibody or antibody against CDC42SE1 could matter depends on whether native CDC42SE1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDC42SE1 is annotated at the cell surface, where native CDC42SE1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CDC42SE1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CDC42SE1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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