DOCK11

Protein identityUniProt · HPA

UniProt accession

Q5JSL3

Gene

DOCK11

Ensembl

ENSG00000147251

Chromosome

X

Canonical length

2073 aa

Protein class

Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable guanyl-nucleotide exchange factor activity. Involved in positive regulation of filopodium assembly. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

2073 residues, UniProt reviewed canonical sequence.

>Q5JSL3|DOCK11
     1  MAEVRKFTKR LSKPGTAAEL RQSVSEAVRG SVVLEKAKVV EPLDYENVIA QRKTQIYSDP
    61  LRDLLMFPME DISISVIGRQ RRTVQSTVPE DAEKRAQSLF VKECIKTYST DWHVVNYKYE
   121  DFSGDFRMLP CKSLRPEKIP NHVFEIDEDC EKDEDSSSLC SQKGGVIKQG WLHKANVNST
   181  ITVTMKVFKR RYFYLTQLPD GSYILNSYKD EKNSKESKGC IYLDACIDVV QCPKMRRHAF
   241  ELKMLDKYSH YLAAETEQEM EEWLITLKKI IQINTDSLVQ EKKETVETAQ DDETSSQGKA
   301  ENIMASLERS MHPELMKYGR ETEQLNKLSR GDGRQNLFSF DSEVQRLDFS GIEPDIKPFE
   361  EKCNKRFLVN CHDLTFNILG QIGDNAKGPP TNVEPFFINL ALFDVKNNCK ISADFHVDLN
   421  PPSVREMLWG SSTQLASDGS PKGSSPESYI HGIAESQLRY IQQGIFSVTN PHPEIFLVAR
   481  IEKVLQGNIT HCAEPYIKNS DPVKTAQKVH RTAKQVCSRL GQYRMPFAWA ARPIFKDTQG
   541  SLDLDGRFSP LYKQDSSKLS SEDILKLLSE YKKPEKTKLQ IIPGQLNITV ECVPVDLSNC
   601  ITSSYVPLKP FEKNCQNITV EVEEFVPEMT KYCYPFTIYK NHLYVYPLQL KYDSQKTFAK
   661  ARNIAVCVEF RDSDESDASA LKCIYGKPAG SVFTTNAYAV VSHHNQNPEF YDEIKIELPI
   721  HLHQKHHLLF TFYHVSCEIN TKGTTKKQDT VETPVGFAWV PLLKDGRIIT FEQQLPVSAN
   781  LPPGYLNLND AESRRQCNVD IKWVDGAKPL LKIKSHLEST IYTQDLHVHK FFHHCQLIQS
   841  GSKEVPGELI KYLKCLHAME IQVMIQFLPV ILMQLFRVLT NMTHEDDVPI NCTMVLLHIV
   901  SKCHEEGLDS YLRSFIKYSF RPEKPSAPQA QLIHETLATT MIAILKQSAD FLSINKLLKY
   961  SWFFFEIIAK SMATYLLEEN KIKLPRGQRF PETYHHVLHS LLLAIIPHVT IRYAEIPDES
  1021  RNVNYSLASF LKRCLTLMDR GFIFNLINDY ISGFSPKDPK VLAEYKFEFL QTICNHEHYI
  1081  PLNLPMAFAK PKLQRVQDSN LEYSLSDEYC KHHFLVGLLL RETSIALQDN YEIRYTAISV
  1141  IKNLLIKHAF DTRYQHKNQQ AKIAQLYLPF VGLLLENIQR LAGRDTLYSC AAMPNSASRD
  1201  EFPCGFTSPA NRGSLSTDKD TAYGSFQNGH GIKREDSRGS LIPEGATGFP DQGNTGENTR
  1261  QSSTRSSVSQ YNRLDQYEIR SLLMCYLYIV KMISEDTLLT YWNKVSPQEL INILILLEVC
  1321  LFHFRYMGKR NIARVHDAWL SKHFGIDRKS QTMPALRNRS GVMQARLQHL SSLESSFTLN
  1381  HSSTTTEADI FHQALLEGNT ATEVSLTVLD TISFFTQCFK TQLLNNDGHN PLMKKVFDIH
  1441  LAFLKNGQSE VSLKHVFASL RAFISKFPSA FFKGRVNMCA AFCYEVLKCC TSKISSTRNE
  1501  ASALLYLLMR NNFEYTKRKT FLRTHLQIII AVSQLIADVA LSGGSRFQES LFIINNFANS
  1561  DRPMKATAFP AEVKDLTKRI RTVLMATAQM KEHEKDPEML IDLQYSLAKS YASTPELRKT
  1621  WLDSMAKIHV KNGDFSEAAM CYVHVAALVA EFLHRKKLFP NGCSAFKKIT PNIDEEGAMK
  1681  EDAGMMDVHY SEEVLLELLE QCVDGLWKAE RYEIISEISK LIVPIYEKRR EFEKLTQVYR
  1741  TLHGAYTKIL EVMHTKKRLL GTFFRVAFYG QSFFEEEDGK EYIYKEPKLT GLSEISLRLV
  1801  KLYGEKFGTE NVKIIQDSDK VNAKELDPKY AHIQVTYVKP YFDDKELTER KTEFERNHNI
  1861  SRFVFEAPYT LSGKKQGCIE EQCKRRTILT TSNSFPYVKK RIPINCEQQI NLKPIDVATD
  1921  EIKDKTAELQ KLCSSTDVDM IQLQLKLQGC VSVQVNAGPL AYARAFLNDS QASKYPPKKV
  1981  SELKDMFRKF IQACSIALEL NERLIKEDQV EYHEGLKSNF RDMVKELSDI IHEQILQEDT
  2041  MHSPWMSNTL HVFCAISGTS SDRGYGSPRY AEV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DOCK11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.3

Highest tissue expression

52 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DOCK11.

Disease | AllUniProt

Conditions DOCK11 is implicated in, by any mechanism.

• Autoinflammatory disease, multisystem, with immune dysregulation, X-linked (ADMIDX) MIM:301109

Disease | GeneticClinVar

14 pathogenic / likely-pathogenic of 605 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Autoinflammatory disease, multisystem, with immune dysregulation, X-linked
• DOCK11 deficiency
• Inborn error of hematopoiesis and immunity with systemic inflammation and normocytic anemia
• Thyroid cancer, nonmedullary, 1

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.37

gnomAD pLI

0.01

gnomAD missense Z

2.68

DepMap mean gene effect

0.15

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• B cell homeostasis
• marginal zone B cell differentiation
• positive regulation of filopodium assembly
• positive regulation of GTPase activity
• regulation of Rho protein signal transduction
• small GTPase-mediated signal transduction

Molecular functions

• guanyl-nucleotide exchange factor activity
• small GTPase binding

Cellular components

• cytosol

Protein domainsUniProt · Pfam · InterPro

• Pleckstrin homology domain
• PH-like domain superfamily
• Armadillo-type fold
• Dedicator of cytokinesis C/D, N-terminal
• Dedicator of cytokinesis
• C2 DOCK-type domain
• DOCKER domain
• C2 domain superfamily
• Dedicator of cytokinesis D, C2 domain
• Dedicator of cytokinesis, C-terminal, lobe A
• Dedicator of cytokinesis, C-terminal, lobe C
• DOCKER, Lobe A
• DOCKER, Lobe B
• DOCKER, Lobe C
• PH domain
• DHR-2, Lobe A
• Dedicator of cytokinesis C/D, N terminal
• C2 domain in Dock180 and Zizimin proteins
• DHR-2, Lobe C
• DHR-2, Lobe B

KeywordsUniProt

• Guanine-nucleotide releasing factor
• Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of DOCK11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CDC42
• DOCK9
• YWHAB
• YWHAG
• YWHAH
• YWHAQ
• YWHAZ