Seroatlas · Human Serome Atlas

PARD6B

Partitioning defective 6 homolog beta

Also known as: PAR-6B, PAR6B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BYG5
Gene: PARD6B
Ensembl: ENSG00000124171
Chromosome: 20
Canonical length: 372 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Cell Junctions,Cytosol

OverviewNCBI Gene

This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cytoplasmic protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

372 residues, UniProt reviewed canonical sequence.

>Q9BYG5|PARD6B
     1  MNRSHRHGAG SGCLGTMEVK SKFGAEFRRF SLERSKPGKF EEFYGLLQHV HKIPNVDVLV
    61  GYADIHGDLL PINNDDNYHK AVSTANPLLR IFIQKKEEAD YSAFGTDTLI KKKNVLTNVL
   121  RPDNHRKKPH IVISMPQDFR PVSSIIDVDI LPETHRRVRL YKYGTEKPLG FYIRDGSSVR
   181  VTPHGLEKVP GIFISRLVPG GLAQSTGLLA VNDEVLEVNG IEVSGKSLDQ VTDMMIANSR
   241  NLIITVRPAN QRNNVVRNSR TSGSSGQSTD NSLLGYPQQI EPSFEPEDED SEEDDIIIED
   301  NGVPQQIPKA VPNTESLESL TQIELSFESG QNGFIPSNEV SLAAIASSSN TEFETHAPDQ
   361  KLLEEDGTII TL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PARD6B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

kidney: 15 nTPM
retina: 8.1 nTPM
epididymis: 7.6 nTPM
stomach: 5.4 nTPM
lung: 5 nTPM
pancreas: 4.3 nTPM

Single-cell type

endometrial glandular cells: 426 nCPM
urothelial cells: 311 nCPM
ocular epithelial cells: 299 nCPM
alveolar cells type 1: 286 nCPM
renal collecting duct principal cells: 239 nCPM
endometrial luminal cells: 237 nCPM

Immune cell

naive CD4 T-cell: 2.2 nTPM
NK-cell: 1.5 nTPM
eosinophil: 1.4 nTPM
MAIT T-cell: 1.4 nTPM
naive CD8 T-cell: 1.4 nTPM
gdT-cell: 1.3 nTPM

Brain region

choroid plexus: 21 nTPM
cerebellum: 11 nTPM
hippocampal formation: 9.1 nTPM
white matter: 8.4 nTPM
midbrain: 8.1 nTPM
hypothalamus: 7.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.36
gnomAD pLI: 0.93
gnomAD missense Z: 1.39
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PARD6B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PARD6B as an antibody target. Whether an autoantibody or antibody against PARD6B could matter depends on whether native PARD6B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PARD6B is annotated at the cell surface, where native PARD6B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PARD6B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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