Seroatlas · Human Serome Atlas

CDC42EP2

Cdc42 effector protein 2

Also known as: BORG1, BORG1_HUMAN, CEP2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O14613
Gene
CDC42EP2
Ensembl
ENSG00000149798
Chromosome
11
Canonical length
210 aa
Protein class
Predicted intracellular proteins
Subcellular location
Microtubules,Cytosol

OverviewNCBI Gene

CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of CDC42. Coexpression of this protein with CDC42 suggested a role of this protein in actin filament assembly and cell shape control. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

210 residues, UniProt reviewed canonical sequence.

>O14613|CDC42EP2
     1  MSTKVPIYLK RGSRKGKKEK LRDLLSSDMI SPPLGDFRHT IHIGSGGGSD MFGDISFLQG
    61  KFHLLPGTMV EGPEEDGTFD LPFQFTRTAT VCGRELPDGP SPLLKNAISL PVIGGPQALT
   121  LPTAQAPPKP PRLHLETPQP SPQEGGSVDI WRIPETGSPN SGLTPESGAE EPFLSNASSL
   181  LSLHVDLGPS ILDDVLQIMD QDLDSMQIPT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDC42EP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.64
Highest tissue expression
40 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 40 nTPM
  • spinal cord: 24 nTPM
  • heart muscle: 22 nTPM
  • breast: 22 nTPM
  • lung: 18 nTPM
  • urinary bladder: 18 nTPM

Single-cell type

  • podocytes: 18 nCPM
  • oligodendrocytes: 17 nCPM
  • renal collecting duct principal cells: 6.8 nCPM
  • papillary tip epithelial cells: 5.7 nCPM
  • renal connecting tubule cells: 2.2 nCPM
  • lymphatic endothelial cells: 1.7 nCPM

Immune cell

  • neutrophil: 173 nTPM
  • intermediate monocyte: 120 nTPM
  • non-classical monocyte: 91 nTPM
  • classical monocyte: 51 nTPM
  • total PBMC: 18 nTPM
  • myeloid DC: 11 nTPM

Brain region

  • white matter: 89 nTPM
  • medulla oblongata: 51 nTPM
  • basal ganglia: 51 nTPM
  • midbrain: 48 nTPM
  • cerebral cortex: 48 nTPM
  • pons: 45 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.77
gnomAD pLI
0.04
gnomAD missense Z
0.52
DepMap mean gene effect
-0.22
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CDC42EP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDC42EP2 as an antibody target. Whether an autoantibody or antibody against CDC42EP2 could matter depends on whether native CDC42EP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDC42EP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDC42EP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CDC42EP2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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