Seroatlas · Human Serome Atlas

CDC42EP1

Cdc42 effector protein 1

Also known as: Borg5, BORG5_HUMAN, CEP1, MSE55

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q00587
Gene
CDC42EP1
Ensembl
ENSG00000128283
Chromosome
22
Canonical length
391 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Plasma membrane,Actin filaments

OverviewNCBI Gene

CDC42 is a member of the Rho GTPase family that regulates multiple cellular activities, including actin polymerization. The protein encoded by this gene is a CDC42 binding protein that mediates actin cytoskeleton reorganization at the plasma membrane. This protein is secreted and is primarily found in bone marrow. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

391 residues, UniProt reviewed canonical sequence.

>Q00587|CDC42EP1
     1  MPGPQGGRGA ATMSLGKLSP VGWVSSSQGK RRLTADMISH PLGDFRHTMH VGRGGDVFGD
    61  TSFLSNHGGS SGSTHRSPRS FLAKKLQLVR RVGAPPRRMA SPPAPSPAPP AISPIIKNAI
   121  SLPQLNQAAY DSLVVGKLSF DSSPTSSTDG HSSYGLDSGF CTISRLPRSE KPHDRDRDGS
   181  FPSEPGLRRS DSLLSFRLDL DLGPSLLSEL LGVMSLPEAP AAETPAPAAN PPAPTANPTG
   241  PAANPPATTA NPPAPAANPS APAATPTGPA ANPPAPAASS TPHGHCPNGV TAGLGPVAEV
   301  KSSPVGGGPR GPAGPALGRH WGAGWDGGHH YPEMDARQER VEVLPQARAS WESLDEEWRA
   361  PQAGSRTPVP STVQANTFEF ADAEEDDEVK V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDC42EP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.71
Highest tissue expression
159 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 159 nTPM
  • stomach: 152 nTPM
  • liver: 127 nTPM
  • spinal cord: 123 nTPM
  • salivary gland: 102 nTPM
  • esophagus: 92 nTPM

Single-cell type

  • esophageal apical cells: 379 nCPM
  • pancreatic duct cells: 196 nCPM
  • fallopian secretory cells: 174 nCPM
  • mucous neck cells: 158 nCPM
  • extravillous trophoblasts: 157 nCPM
  • cholangiocytes: 148 nCPM

Immune cell

  • classical monocyte: 7.3 nTPM
  • total PBMC: 3.4 nTPM
  • myeloid DC: 2.4 nTPM
  • intermediate monocyte: 1.9 nTPM
  • basophil: 0.4 nTPM
  • NK-cell: 0.4 nTPM

Brain region

  • white matter: 289 nTPM
  • basal ganglia: 207 nTPM
  • midbrain: 202 nTPM
  • medulla oblongata: 200 nTPM
  • cerebellum: 172 nTPM
  • thalamus: 165 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.73
gnomAD pLI
0
gnomAD missense Z
-0.79
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CDC42EP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDC42EP1 as an antibody target. Whether an autoantibody or antibody against CDC42EP1 could matter depends on whether native CDC42EP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDC42EP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDC42EP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CDC42EP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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