Seroatlas · Human Serome Atlas

NEK6

Serine/threonine-protein kinase Nek6

Also known as: NEK6_HUMAN, SID6-1512

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HC98
Gene: NEK6
Ensembl: ENSG00000119408
Chromosome: 9
Canonical length: 313 aa
Protein class: Enzymes, Predicted intracellular proteins, Transporters
Subcellular location: Nucleoplasm,Centriolar satellite,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a kinase required for progression through the metaphase portion of mitosis. Inhibition of the encoded protein can lead to apoptosis. This protein also can enhance tumorigenesis by suppressing tumor cell senescence. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Canonical amino-acid sequenceUniProt

313 residues, UniProt reviewed canonical sequence.

>Q9HC98|NEK6
     1  MAGQPGHMPH GGSSNNLCHT LGPVHPPDPQ RHPNTLSFRC SLADFQIEKK IGRGQFSEVY
    61  KATCLLDRKT VALKKVQIFE MMDAKARQDC VKEIGLLKQL NHPNIIKYLD SFIEDNELNI
   121  VLELADAGDL SQMIKYFKKQ KRLIPERTVW KYFVQLCSAV EHMHSRRVMH RDIKPANVFI
   181  TATGVVKLGD LGLGRFFSSE TTAAHSLVGT PYYMSPERIH ENGYNFKSDI WSLGCLLYEM
   241  AALQSPFYGD KMNLFSLCQK IEQCDYPPLP GEHYSEKLRE LVSMCICPDP HQRPDIGYVH
   301  QVAKQMHIWM SST

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NEK6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 64 nTPM

Expression across tissuesHPA

Tissue

liver: 64 nTPM
basal ganglia: 33 nTPM
cerebral cortex: 32 nTPM
appendix: 31 nTPM
tonsil: 30 nTPM
amygdala: 29 nTPM

Single-cell type

extravillous trophoblasts: 173 nCPM
hofbauer cells: 160 nCPM
migrating cytotrophoblasts: 157 nCPM
late spermatids: 153 nCPM
alveolar cells type 1: 105 nCPM
tuft cells: 104 nCPM

Immune cell

eosinophil: 77 nTPM
neutrophil: 59 nTPM
memory B-cell: 53 nTPM
classical monocyte: 48 nTPM
non-classical monocyte: 42 nTPM
intermediate monocyte: 32 nTPM

Brain region

medulla oblongata: 108 nTPM
thalamus: 96 nTPM
midbrain: 88 nTPM
hypothalamus: 80 nTPM
spinal cord: 75 nTPM
cerebral cortex: 74 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.61
gnomAD pLI: 0.04
gnomAD missense Z: 1.95
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NEK6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NEK6 as an antibody target. Whether an autoantibody or antibody against NEK6 could matter depends on whether native NEK6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NEK6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NEK6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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