Seroatlas · Human Serome Atlas

CDC42EP3

Cdc42 effector protein 3

Also known as: BORG2, BORG2_HUMAN, CEP3, UB1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UKI2
Gene
CDC42EP3
Ensembl
ENSG00000163171
Chromosome
2
Canonical length
254 aa
Protein class
Predicted intracellular proteins
Subcellular location
Plasma membrane,Actin filaments

OverviewNCBI Gene

This gene encodes a member of a small family of guanosine triphosphate (GTP) metabolizing proteins that contain a CRIB (Cdc42, Rac interactive binding) domain. Members of this family of proteins act as effectors of CDC42 function. The encoded protein is involved in actin cytoskeleton re-organization during cell shape changes, including pseudopodia formation. A pseudogene of this gene is found on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

Canonical amino-acid sequenceUniProt

254 residues, UniProt reviewed canonical sequence.

>Q9UKI2|CDC42EP3
     1  MPAKTPIYLK AANNKKGKKF KLRDILSPDM ISPPLGDFRH TIHIGKEGQH DVFGDISFLQ
    61  GNYELLPGNQ EKAHLGQFPG HNEFFRANST SDSVFTETPS PVLKNAISLP TIGGSQALML
   121  PLLSPVTFNS KQESFGPAKL PRLSCEPVME EKAQEKSSLL ENGTVHQGDT SWGSSGSASQ
   181  SSQGRDSHSS SLSEQYPDWP AEDMFDHPTP CELIKGKTKS EESLSDLTGS LLSLQLDLGP
   241  SLLDEVLNVM DKNK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDC42EP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.61
Highest tissue expression
101 nTPM

Expression across tissuesHPA

Tissue

  • seminal vesicle: 101 nTPM
  • smooth muscle: 90 nTPM
  • prostate: 88 nTPM
  • endometrium: 87 nTPM
  • bone marrow: 82 nTPM
  • heart muscle: 56 nTPM

Single-cell type

  • neutrophils: 1,010 nCPM
  • melanocytes: 564 nCPM
  • thymic myoid cells: 315 nCPM
  • mast cells: 314 nCPM
  • podocytes: 296 nCPM
  • late spermatids: 227 nCPM

Immune cell

  • neutrophil: 190 nTPM
  • non-classical monocyte: 120 nTPM
  • classical monocyte: 88 nTPM
  • MAIT T-cell: 75 nTPM
  • gdT-cell: 70 nTPM
  • total PBMC: 62 nTPM

Brain region

  • cerebral cortex: 61 nTPM
  • choroid plexus: 54 nTPM
  • hypothalamus: 21 nTPM
  • hippocampal formation: 21 nTPM
  • pons: 19 nTPM
  • basal ganglia: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.96
gnomAD pLI
0.19
gnomAD missense Z
-0.06
DepMap mean gene effect
0.13
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CDC42EP3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDC42EP3 as an antibody target. Whether an autoantibody or antibody against CDC42EP3 could matter depends on whether native CDC42EP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDC42EP3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDC42EP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CDC42EP3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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