Seroatlas · Human Serome Atlas

CDC42EP5

Cdc42 effector protein 5

Also known as: Borg3, BORG3_HUMAN, CEP5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6NZY7
Gene
CDC42EP5
Ensembl
ENSG00000167617
Chromosome
19
Canonical length
148 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Primary cilium,Cytosol

OverviewNCBI Gene

Cell division control protein 42 (CDC42), a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg (binder of Rho GTPases) family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to CDC42 and regulate its function negatively. The encoded protein may inhibit c-Jun N-terminal kinase (JNK) independently of CDC42 binding. The protein may also play a role in septin organization and inducing pseudopodia formation in fibroblasts [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

148 residues, UniProt reviewed canonical sequence.

>Q6NZY7|CDC42EP5
     1  MPVLKQLGPA QPKKRPDRGA LSISAPLGDF RHTLHVGRGG DAFGDTSFLS RHGGGPPPEP
    61  RAPPAGAPRS PPPPAVPQSA APSPADPLLS FHLDLGPSML DAVLGVMDAA RPEAAAAKPD
   121  AEPRPGTQPP QARCRPNADL ELNDVIGL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDC42EP5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.67
Highest tissue expression
80 nTPM

Expression across tissuesHPA

Tissue

  • colon: 80 nTPM
  • prostate: 58 nTPM
  • small intestine: 50 nTPM
  • salivary gland: 40 nTPM
  • urinary bladder: 38 nTPM
  • blood vessel: 35 nTPM

Single-cell type

  • papillary tip epithelial cells: 35 nCPM
  • prostatic club cells: 19 nCPM
  • prostatic hillock cells: 12 nCPM
  • endometrial secretory cells: 12 nCPM
  • urothelial cells: 10 nCPM
  • goblet cells: 8.2 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • medulla oblongata: 4.2 nTPM
  • pons: 2.5 nTPM
  • white matter: 1.9 nTPM
  • amygdala: 1.6 nTPM
  • cerebral cortex: 1.6 nTPM
  • basal ganglia: 1.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.86
gnomAD pLI
0.32
gnomAD missense Z
1
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CDC42EP5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDC42EP5 as an antibody target. Whether an autoantibody or antibody against CDC42EP5 could matter depends on whether native CDC42EP5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDC42EP5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDC42EP5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CDC42EP5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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