Seroatlas · Human Serome Atlas

TNK2

Activated CDC42 kinase 1

Also known as: ACK, ACK1, ACK1_HUMAN, p21cdc42Hs

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q07912
Gene: TNK2
Ensembl: ENSG00000061938
Chromosome: 3
Canonical length: 1038 aa
Protein class: Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Vesicles,Plasma membrane
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1038 residues, UniProt reviewed canonical sequence.

>Q07912|TNK2
     1  MQPEEGTGWL LELLSEVQLQ QYFLRLRDDL NVTRLSHFEY VKNEDLEKIG MGRPGQRRLW
    61  EAVKRRKALC KRKSWMSKVF SGKRLEAEFP PHHSQSTFRK TSPAPGGPAG EGPLQSLTCL
   121  IGEKDLRLLE KLGDGSFGVV RRGEWDAPSG KTVSVAVKCL KPDVLSQPEA MDDFIREVNA
   181  MHSLDHRNLI RLYGVVLTPP MKMVTELAPL GSLLDRLRKH QGHFLLGTLS RYAVQVAEGM
   241  GYLESKRFIH RDLAARNLLL ATRDLVKIGD FGLMRALPQN DDHYVMQEHR KVPFAWCAPE
   301  SLKTRTFSHA SDTWMFGVTL WEMFTYGQEP WIGLNGSQIL HKIDKEGERL PRPEDCPQDI
   361  YNVMVQCWAH KPEDRPTFVA LRDFLLEAQP TDMRALQDFE EPDKLHIQMN DVITVIEGRA
   421  ENYWWRGQNT RTLCVGPFPR NVVTSVAGLS AQDISQPLQN SFIHTGHGDS DPRHCWGFPD
   481  RIDELYLGNP MDPPDLLSVE LSTSRPPQHL GGVKKPTYDP VSEDQDPLSS DFKRLGLRKP
   541  GLPRGLWLAK PSARVPGTKA SRGSGAEVTL IDFGEEPVVP ALRPCAPSLA QLAMDACSLL
   601  DETPPQSPTR ALPRPLHPTP VVDWDARPLP PPPAYDDVAQ DEDDFEICSI NSTLVGAGVP
   661  AGPSQGQTNY AFVPEQARPP PPLEDNLFLP PQGGGKPPSS AQTAEIFQAL QQECMRQLQA
   721  PAGSPAPSPS PGGDDKPQVP PRVPIPPRPT RPHVQLSPAP PGEEETSQWP GPASPPRVPP
   781  REPLSPQGSR TPSPLVPPGS SPLPPRLSSS PGKTMPTTQS FASDPKYATP QVIQAPGPRA
   841  GPCILPIVRD GKKVSSTHYY LLPERPSYLE RYQRFLREAQ SPEEPTPLPV PLLLPPPSTP
   901  APAAPTATVR PMPQAALDPK ANFSTNNSNP GARPPPPRAT ARLPQRGCPG DGPEAGRPAD
   961  KIQMAMVHGV TTEECQAALQ CHGWSVQRAA QYLKVEQLFG LGLRPRGECH KVLEMFDWNL
  1021  EQAGCHLLGS WGPAHHKR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TNK2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 127 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 127 nTPM
amygdala: 116 nTPM
hippocampal formation: 98 nTPM
basal ganglia: 90 nTPM
hypothalamus: 85 nTPM
pituitary gland: 82 nTPM

Single-cell type

oligodendrocyte progenitor cells: 391 nCPM
myonuclei: 115 nCPM
esophageal apical cells: 105 nCPM
corticotrophs: 100 nCPM
oligodendrocytes: 95 nCPM
bergmann glia: 94 nCPM

Immune cell

neutrophil: 2.6 nTPM
naive B-cell: 2.5 nTPM
plasmacytoid DC: 1.5 nTPM
basophil: 1.4 nTPM
intermediate monocyte: 1.4 nTPM
non-classical monocyte: 1.4 nTPM

Brain region

cerebral cortex: 211 nTPM
medulla oblongata: 177 nTPM
amygdala: 176 nTPM
pons: 161 nTPM
midbrain: 144 nTPM
basal ganglia: 143 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TNK2.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 523 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Epileptic encephalopathy

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.8
gnomAD pLI: 0
gnomAD missense Z: -0.2
DepMap mean gene effect: 0.13
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Protein kinase domain
Serine-threonine/tyrosine-protein kinase, catalytic domain
SH3 domain
Tyrosine-protein kinase, active site
Protein kinase-like domain superfamily
Cdc42 binding domain-like
Protein kinase, ATP binding site
Tyrosine-protein kinase, catalytic domain
SH3-like domain superfamily
TNK(ACK)-like non-receptor tyrosine-protein kinases, SAM domain
EGFR Signaling Regulator Kinase
ACK/TNK-like, SAM domain
Protein tyrosine and serine/threonine kinase
GTPase binding
Variant SH3 domain
SAM domain-like
Mig-6 domain
Activated CDC42 kinase 1, UBA domain
Cdc42 binding domain-like superfamily
EGFR receptor inhibitor Mig-6

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TNK2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TNK2 as an antibody target. Whether an autoantibody or antibody against TNK2 could matter depends on whether native TNK2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TNK2 is annotated at the cell surface, where native TNK2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TNK2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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