Seroatlas · Human Serome Atlas

CCPG1

Cell cycle progression protein 1

Also known as: CCPG1_HUMAN, CPR8, KIAA1254

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9ULG6
Gene: CCPG1
Ensembl: ENSG00000260916
Chromosome: 15
Canonical length: 757 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Endoplasmic reticulum,Golgi apparatus

OverviewNCBI Gene

Involved in positive regulation of cell cycle and positive regulation of cell population proliferation. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

757 residues, UniProt reviewed canonical sequence.

>Q9ULG6|CCPG1
     1  MSENSSDSDS SCGWTVISHE GSDIEMLNSV TPTDSCEPAP ECSSLEQEEL QALQIEQGES
    61  SQNGTVLMEE TAYPALEETS STIEAEEQKI PEDSIYIGTA SDDSDIVTLE PPKLEEIGNQ
   121  EVVIVEEAQS SEDFNMGSSS SSQYTFCQPE TVFSSQPSDD ESSSDETSNQ PSPAFRRRRA
   181  RKKTVSASES EDRLVAEQET EPSKELSKRQ FSSGLNKCVI LALVIAISMG FGHFYGTIQI
   241  QKRQQLVRKI HEDELNDMKD YLSQCQQEQE SFIDYKSLKE NLARCWTLTE AEKMSFETQK
   301  TNLATENQYL RVSLEKEEKA LSSLQEELNK LREQIRILED KGTSTELVKE NQKLKQHLEE
   361  EKQKKHSFLS QRETLLTEAK MLKRELERER LVTTALRGEL QQLSGSQLHG KSDSPNVYTE
   421  KKEIAILRER LTELERKLTF EQQRSDLWER LYVEAKDQNG KQGTDGKKKG GRGSHRAKNK
   481  SKETFLGSVK ETFDAMKNST KEFVRHHKEK IKQAKEAVKE NLKKFSDSVK STFRHFKDTT
   541  KNIFDEKGNK RFGATKEAAE KPRTVFSDYL HPQYKAPTEN HHNRGPTMQN DGRKEKPVHF
   601  KEFRKNTNSK KCSPGHDCRE NSHSFRKACS GVFDCAQQES MSLFNTVVNP IRMDEFRQII
   661  QRYMLKELDT FCHWNELDQF INKFFLNGVF IHDQKLFTDF VNDVKDYLRN MKEYEVDNDG
   721  VFEKLDEYIY RHFFGHTFSP PYGPRSVYIK PCHYSSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCPG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 80 nTPM

Expression across tissuesHPA

Tissue

pancreas: 80 nTPM
thyroid gland: 79 nTPM
salivary gland: 72 nTPM
parathyroid gland: 69 nTPM
liver: 63 nTPM
bone marrow: 60 nTPM

Single-cell type

brain inhibitory neurons: 261 nCPM
brain excitatory neurons: 259 nCPM
other brain neurons: 221 nCPM
renal collecting duct intercalated cells: 168 nCPM
renal collecting duct principal cells: 141 nCPM
neutrophil progenitors: 140 nCPM

Immune cell

neutrophil: 298 nTPM
eosinophil: 280 nTPM
basophil: 222 nTPM
non-classical monocyte: 85 nTPM
classical monocyte: 60 nTPM
intermediate monocyte: 51 nTPM

Brain region

choroid plexus: 111 nTPM
basal ganglia: 90 nTPM
hypothalamus: 89 nTPM
cerebral cortex: 89 nTPM
cerebellum: 81 nTPM
amygdala: 80 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.56
gnomAD pLI: 0
gnomAD missense Z: 0.99
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

Cell Cycle Progression and Pre-B-cell Leukemia Transcription Factor-Interacting

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCPG1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCPG1 as an antibody target. Whether an autoantibody or antibody against CCPG1 could matter depends on whether native CCPG1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCPG1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCPG1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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