Seroatlas · Human Serome Atlas

CDC42SE2

CDC42 small effector protein 2

Also known as: C42S2_HUMAN, FLJ21967, SPEC2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NRR3
Gene
CDC42SE2
Ensembl
ENSG00000158985
Chromosome
5
Canonical length
84 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Enables signaling adaptor activity. Involved in regulation of signal transduction. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

84 residues, UniProt reviewed canonical sequence.

>Q9NRR3|CDC42SE2
     1  MSEFWLCFNC CIAEQPQPKR RRRIDRSMIG EPTNFVHTAH VGSGDLFSGM NSVSSIQNQM
    61  QSKGGYGGGM PANVQMQLVD TKAG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDC42SE2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.6
Highest tissue expression
76 nTPM

Expression across tissuesHPA

Tissue

  • lymph node: 76 nTPM
  • bone marrow: 74 nTPM
  • tonsil: 62 nTPM
  • spleen: 55 nTPM
  • appendix: 51 nTPM
  • rectum: 45 nTPM

Single-cell type

  • t-cells: 1,260 nCPM
  • neutrophils: 955 nCPM
  • nk-cells: 927 nCPM
  • b-cells: 877 nCPM
  • neutrophil progenitors: 791 nCPM
  • innate lymphoid cells: 619 nCPM

Immune cell

  • basophil: 234 nTPM
  • total PBMC: 181 nTPM
  • naive CD8 T-cell: 149 nTPM
  • memory CD8 T-cell: 138 nTPM
  • eosinophil: 135 nTPM
  • naive CD4 T-cell: 132 nTPM

Brain region

  • white matter: 60 nTPM
  • cerebral cortex: 57 nTPM
  • basal ganglia: 51 nTPM
  • hippocampal formation: 48 nTPM
  • spinal cord: 47 nTPM
  • midbrain: 47 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.62
gnomAD pLI
0.77
gnomAD missense Z
1.21
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CDC42SE2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDC42SE2 as an antibody target. Whether an autoantibody or antibody against CDC42SE2 could matter depends on whether native CDC42SE2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDC42SE2 is annotated at the cell surface, where native CDC42SE2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CDC42SE2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CDC42SE2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...