Seroatlas · Human Serome Atlas

WASL

Actin nucleation-promoting factor WASL

Also known as: N-WASP, NWASP, WASL_HUMAN, WASPB

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O00401
Gene
WASL
Ensembl
ENSG00000106299
Chromosome
7
Canonical length
505 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoli,Cytosol

OverviewNCBI Gene

This gene encodes a member of the Wiskott-Aldrich syndrome (WAS) protein family. Wiskott-Aldrich syndrome proteins share similar domain structure, and associate with a variety of signaling molecules to alter the actin cytoskeleton. The encoded protein is highly expressed in neural tissues, and interacts with several proteins involved in cytoskeletal organization, including cell division control protein 42 (CDC42) and the actin-related protein-2/3 (ARP2/3) complex. The encoded protein may be involved in the formation of long actin microspikes, and in neurite extension. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

505 residues, UniProt reviewed canonical sequence.

>O00401|WASL
     1  MSSVQQQPPP PRRVTNVGSL LLTPQENESL FTFLGKKCVT MSSAVVQLYA ADRNCMWSKK
    61  CSGVACLVKD NPQRSYFLRI FDIKDGKLLW EQELYNNFVY NSPRGYFHTF AGDTCQVALN
   121  FANEEEAKKF RKAVTDLLGR RQRKSEKRRD PPNGPNLPMA TVDIKNPEIT TNRFYGPQVN
   181  NISHTKEKKK GKAKKKRLTK ADIGTPSNFQ HIGHVGWDPN TGFDLNNLDP ELKNLFDMCG
   241  ISEAQLKDRE TSKVIYDFIE KTGGVEAVKN ELRRQAPPPP PPSRGGPPPP PPPPHNSGPP
   301  PPPARGRGAP PPPPSRAPTA APPPPPPSRP SVAVPPPPPN RMYPPPPPAL PSSAPSGPPP
   361  PPPSVLGVGP VAPPPPPPPP PPPGPPPPPG LPSDGDHQVP TTAGNKAALL DQIREGAQLK
   421  KVEQNSRPVS CSGRDALLDQ IRQGIQLKSV ADGQESTPPT PAPTSGIVGA LMEVMQKRSK
   481  AIHSSDEDED EDDEEDFEDD DEWED

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WASL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
44 nTPM

Expression across tissuesHPA

Tissue

  • liver: 44 nTPM
  • kidney: 41 nTPM
  • colon: 40 nTPM
  • small intestine: 39 nTPM
  • parathyroid gland: 38 nTPM
  • urinary bladder: 36 nTPM

Single-cell type

  • esophageal apical cells: 421 nCPM
  • urothelial cells: 387 nCPM
  • podocytes: 368 nCPM
  • ocular epithelial cells: 261 nCPM
  • colonocytes: 205 nCPM
  • cardiomyocytes: 203 nCPM

Immune cell

  • non-classical monocyte: 3 nTPM
  • basophil: 2.5 nTPM
  • NK-cell: 2.5 nTPM
  • memory B-cell: 2 nTPM
  • plasmacytoid DC: 1.9 nTPM
  • classical monocyte: 1.7 nTPM

Brain region

  • hippocampal formation: 105 nTPM
  • cerebral cortex: 102 nTPM
  • basal ganglia: 59 nTPM
  • thalamus: 58 nTPM
  • hypothalamus: 57 nTPM
  • midbrain: 55 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.38
gnomAD pLI
0.88
gnomAD missense Z
2.01
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WASL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WASL as an antibody target. Whether an autoantibody or antibody against WASL could matter depends on whether native WASL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WASL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WASL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/WASL. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...