Seroatlas · Human Serome Atlas

ARPC5

Actin-related protein 2/3 complex subunit 5

Also known as: ARC16, ARPC5_HUMAN, dJ127C7.3, p16-Arc

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O15511
Gene: ARPC5
Ensembl: ENSG00000162704
Chromosome: 1
Canonical length: 151 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Vesicles,Plasma membrane,Cell Junctions,Cytosol

OverviewNCBI Gene

This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p16 subunit, has yet to be determined. Alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

Canonical amino-acid sequenceUniProt

151 residues, UniProt reviewed canonical sequence.

>O15511|ARPC5
     1  MSKNTVSSAR FRKVDVDEYD ENKFVDEEDG GDGQAGPDEG EVDSCLRQGN MTAALQAALK
    61  NPPINTKSQA VKDRAGSIVL KVLISFKAND IEKAVQSLDK NGVDLLMKYI YKGFESPSDN
   121  SSAMLLQWHE KALAAGGVGS IVRVLTARKT V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARPC5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 149 nTPM

Expression across tissuesHPA

Tissue

lymph node: 149 nTPM
appendix: 140 nTPM
tonsil: 123 nTPM
thymus: 122 nTPM
spleen: 114 nTPM
small intestine: 111 nTPM

Single-cell type

megakaryocytes: 2,077 nCPM
neutrophils: 1,600 nCPM
platelets: 1,465 nCPM
neutrophil progenitors: 1,259 nCPM
esophageal apical cells: 983 nCPM
extravillous trophoblasts: 967 nCPM

Immune cell

total PBMC: 1,915 nTPM
neutrophil: 1,862 nTPM
eosinophil: 1,568 nTPM
non-classical monocyte: 1,275 nTPM
basophil: 1,226 nTPM
intermediate monocyte: 1,112 nTPM

Brain region

white matter: 81 nTPM
medulla oblongata: 78 nTPM
thalamus: 55 nTPM
spinal cord: 52 nTPM
cerebellum: 51 nTPM
cerebral cortex: 51 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ARPC5.

Disease | AllUniProt

Conditions ARPC5 is implicated in, by any mechanism.

Immunodeficiency 113 with autoimmunity and autoinflammation (IMD113) MIM:620565

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 20 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Immunodeficiency 113 with autoimmunity and autoinflammation

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.53
gnomAD pLI: 0.82
gnomAD missense Z: 1.63
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARPC5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARPC5 as an antibody target. Whether an autoantibody or antibody against ARPC5 could matter depends on whether native ARPC5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARPC5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARPC5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...