Seroatlas · Human Serome Atlas

ARHGDIA

Rho GDP-dissociation inhibitor 1

Also known as: GDIA1, GDIR1_HUMAN, RHOGDI

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P52565
Gene
ARHGDIA
Ensembl
ENSG00000141522
Chromosome
17
Canonical length
204 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

This gene encodes a protein that plays a key role in the regulation of signaling through Rho GTPases. The encoded protein inhibits the disassociation of Rho family members from GDP (guanine diphosphate), thereby maintaining these factors in an inactive state. Activity of this protein is important in a variety of cellular processes, and expression of this gene may be altered in tumors. Mutations in this gene have been found in individuals with nephrotic syndrome, type 8. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Canonical amino-acid sequenceUniProt

204 residues, UniProt reviewed canonical sequence.

>P52565|ARHGDIA
     1  MAEQEPTAEQ LAQIAAENEE DEHSVNYKPP AQKSIQEIQE LDKDDESLRK YKEALLGRVA
    61  VSADPNVPNV VVTGLTLVCS SAPGPLELDL TGDLESFKKQ SFVLKEGVEY RIKISFRVNR
   121  EIVSGMKYIQ HTYRKGVKID KTDYMVGSYG PRAEEYEFLT PVEEAPKGML ARGSYSIKSR
   181  FTDDDKTDHL SWEWNLTIKK DWKD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARHGDIA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
302 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 302 nTPM
  • adipose tissue: 267 nTPM
  • esophagus: 265 nTPM
  • lung: 263 nTPM
  • spleen: 241 nTPM
  • kidney: 229 nTPM

Single-cell type

  • esophageal apical cells: 364 nCPM
  • extravillous trophoblasts: 341 nCPM
  • neutrophil progenitors: 297 nCPM
  • hofbauer cells: 287 nCPM
  • enterocytes: 277 nCPM
  • syncytiotrophoblasts: 272 nCPM

Immune cell

  • non-classical monocyte: 103 nTPM
  • eosinophil: 88 nTPM
  • intermediate monocyte: 73 nTPM
  • gdT-cell: 65 nTPM
  • memory CD8 T-cell: 63 nTPM
  • MAIT T-cell: 61 nTPM

Brain region

  • pons: 320 nTPM
  • midbrain: 300 nTPM
  • hypothalamus: 281 nTPM
  • medulla oblongata: 270 nTPM
  • cerebral cortex: 255 nTPM
  • thalamus: 237 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ARHGDIA.

Disease | AllUniProt

Conditions ARHGDIA is implicated in, by any mechanism.

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 92 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Nephrotic syndrome, type 8

Disease | ImmuneIEDB

Conditions an epitope on ARHGDIA was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.87
gnomAD pLI
0.04
gnomAD missense Z
1.2
DepMap mean gene effect
0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARHGDIA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARHGDIA as an antibody target. Whether an autoantibody or antibody against ARHGDIA could matter depends on whether native ARHGDIA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARHGDIA is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARHGDIA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ARHGDIA. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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