Seroatlas · Human Serome Atlas

CDC42EP4

Cdc42 effector protein 4

Also known as: BORG4, BORG4_HUMAN, CEP4, KAIA1777, MGC17125, MGC3740

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H3Q1
Gene
CDC42EP4
Ensembl
ENSG00000179604
Chromosome
17
Canonical length
356 aa
Protein class
Predicted intracellular proteins
Subcellular location
Plasma membrane,Actin filaments,Microtubules

OverviewNCBI Gene

The product of this gene is a member of the CDC42-binding protein family. Members of this family interact with Rho family GTPases and regulate the organization of the actin cytoskeleton. This protein has been shown to bind both CDC42 and TC10 GTPases in a GTP-dependent manner. When overexpressed in fibroblasts, this protein was able to induce pseudopodia formation, which suggested a role in inducing actin filament assembly and cell shape control. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

356 residues, UniProt reviewed canonical sequence.

>Q9H3Q1|CDC42EP4
     1  MPILKQLVSS SVHSKRRSRA DLTAEMISAP LGDFRHTMHV GRAGDAFGDT SFLNSKAGEP
    61  DGESLDEQPS SSSSKRSLLS RKFRGSKRSQ SVTRGEREQR DMLGSLRDSA LFVKNAMSLP
   121  QLNEKEAAEK GTSKLPKSLS SSPVKKANDG EGGDEEAGTE EAVPRRNGAA GPHSPDPLLD
   181  EQAFGDLTDL PVVPKATYGL KHAESIMSFH IDLGPSMLGD VLSIMDKEEW DPEEGEGGYH
   241  GDEGAAGTIT QAPPYAVAAP PLARQEGKAG PDLPSLPSHA LEDEGWAAAA PSPGSARSMG
   301  SHTTRDSSSL SSCTSGILEE RSPAFRGPDR ARAAVSRQPD KEFSFMDEEE EDEIRV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDC42EP4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.71
Highest tissue expression
92 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 92 nTPM
  • retina: 91 nTPM
  • cerebellum: 77 nTPM
  • breast: 75 nTPM
  • basal ganglia: 74 nTPM
  • pancreas: 73 nTPM

Single-cell type

  • müller glia: 790 nCPM
  • retinal horizontal cells: 487 nCPM
  • bergmann glia: 304 nCPM
  • respiratory basal cells: 264 nCPM
  • pituicytes/fscs: 263 nCPM
  • esophageal basal cells: 212 nCPM

Immune cell

  • non-classical monocyte: 20 nTPM
  • intermediate monocyte: 8.5 nTPM
  • eosinophil: 5.9 nTPM
  • neutrophil: 5.4 nTPM
  • myeloid DC: 4.3 nTPM
  • basophil: 3.4 nTPM

Brain region

  • medulla oblongata: 229 nTPM
  • white matter: 154 nTPM
  • thalamus: 150 nTPM
  • midbrain: 149 nTPM
  • spinal cord: 147 nTPM
  • hypothalamus: 146 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.9
gnomAD pLI
0.21
gnomAD missense Z
0.33
DepMap mean gene effect
-0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CDC42EP4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDC42EP4 as an antibody target. Whether an autoantibody or antibody against CDC42EP4 could matter depends on whether native CDC42EP4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDC42EP4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDC42EP4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CDC42EP4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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