Seroatlas · Human Serome Atlas

ITGB1

Integrin beta-1

Also known as: CD29, FNRB, GPIIA, ITB1_HUMAN, MDF2, MSK12

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P05556
Gene
ITGB1
Ensembl
ENSG00000150093
Chromosome
10
Canonical length
798 aa
Protein class
Cancer-related genes, CD markers, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Endoplasmic reticulum,Plasma membrane,Focal adhesion sites
Quaternary structure
Homodimer

OverviewNCBI Gene

Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

798 residues, UniProt reviewed canonical sequence.

>P05556|ITGB1
     1  MNLQPIFWIG LISSVCCVFA QTDENRCLKA NAKSCGECIQ AGPNCGWCTN STFLQEGMPT
    61  SARCDDLEAL KKKGCPPDDI ENPRGSKDIK KNKNVTNRSK GTAEKLKPED ITQIQPQQLV
   121  LRLRSGEPQT FTLKFKRAED YPIDLYYLMD LSYSMKDDLE NVKSLGTDLM NEMRRITSDF
   181  RIGFGSFVEK TVMPYISTTP AKLRNPCTSE QNCTSPFSYK NVLSLTNKGE VFNELVGKQR
   241  ISGNLDSPEG GFDAIMQVAV CGSLIGWRNV TRLLVFSTDA GFHFAGDGKL GGIVLPNDGQ
   301  CHLENNMYTM SHYYDYPSIA HLVQKLSENN IQTIFAVTEE FQPVYKELKN LIPKSAVGTL
   361  SANSSNVIQL IIDAYNSLSS EVILENGKLS EGVTISYKSY CKNGVNGTGE NGRKCSNISI
   421  GDEVQFEISI TSNKCPKKDS DSFKIRPLGF TEEVEVILQY ICECECQSEG IPESPKCHEG
   481  NGTFECGACR CNEGRVGRHC ECSTDEVNSE DMDAYCRKEN SSEICSNNGE CVCGQCVCRK
   541  RDNTNEIYSG KFCECDNFNC DRSNGLICGG NGVCKCRVCE CNPNYTGSAC DCSLDTSTCE
   601  ASNGQICNGR GICECGVCKC TDPKFQGQTC EMCQTCLGVC AEHKECVQCR AFNKGEKKDT
   661  CTQECSYFNI TKVESRDKLP QPVQPDPVSH CKEKDVDDCW FYFTYSVNGN NEVMVHVVEN
   721  PECPTGPDII PIVAGVVAGI VLIGLALLLI WKLLMIIHDR REFAKFEKEK MNAKWDTGEN
   781  PIYKSAVTTV VNPKYEGK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ITGB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
663 nTPM

Expression across tissuesHPA

Tissue

  • smooth muscle: 663 nTPM
  • blood vessel: 612 nTPM
  • adipose tissue: 462 nTPM
  • placenta: 432 nTPM
  • seminal vesicle: 403 nTPM
  • heart muscle: 359 nTPM

Single-cell type

  • platelets: 1,112 nCPM
  • endometrial glandular cells: 770 nCPM
  • pancreatic duct cells: 750 nCPM
  • smooth muscle cells: 600 nCPM
  • breast myoepithelial cells: 581 nCPM
  • salivary myoepithelial cells: 559 nCPM

Immune cell

  • T-reg: 267 nTPM
  • memory CD4 T-cell: 192 nTPM
  • memory CD8 T-cell: 139 nTPM
  • total PBMC: 117 nTPM
  • memory B-cell: 110 nTPM
  • non-classical monocyte: 108 nTPM

Brain region

  • medulla oblongata: 151 nTPM
  • thalamus: 148 nTPM
  • white matter: 143 nTPM
  • midbrain: 130 nTPM
  • pons: 126 nTPM
  • spinal cord: 124 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.31
gnomAD pLI
0.98
gnomAD missense Z
3.46
DepMap mean gene effect
-0.21
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ITGB1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ITGB1 as an antibody target. Whether an autoantibody or antibody against ITGB1 could matter depends on whether native ITGB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ITGB1 is annotated at the cell surface, where native ITGB1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ITGB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ITGB1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...