Seroatlas · Human Serome Atlas

PARD6A

Partitioning defective 6 homolog alpha

Also known as: PAR-6, PAR-6A, PAR6A_HUMAN, PAR6alpha, TAX40, TIP-40

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NPB6
Gene
PARD6A
Ensembl
ENSG00000102981
Chromosome
16
Canonical length
346 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Plasma membrane,Cell Junctions,Actin filaments,Cytosol

OverviewNCBI Gene

This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

346 residues, UniProt reviewed canonical sequence.

>Q9NPB6|PARD6A
     1  MARPQRTPAR SPDSIVEVKS KFDAEFRRFA LPRASVSGFQ EFSRLLRAVH QIPGLDVLLG
    61  YTDAHGDLLP LTNDDSLHRA LASGPPPLRL LVQKRAEADS SGLAFASNSL QRRKKGLLLR
   121  PVAPLRTRPP LLISLPQDFR QVSSVIDVDL LPETHRRVRL HKHGSDRPLG FYIRDGMSVR
   181  VAPQGLERVP GIFISRLVRG GLAESTGLLA VSDEILEVNG IEVAGKTLDQ VTDMMVANSH
   241  NLIVTVKPAN QRNNVVRGAS GRLTGPPSAG PGPAEPDSDD DSSDLVIENR QPPSSNGLSQ
   301  GPPCWDLHPG CRHPGTRSSL PSLDDQEQAS SGWGSRIRGD GSGFSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PARD6A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
45 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 45 nTPM
  • testis: 41 nTPM
  • hippocampal formation: 31 nTPM
  • cerebral cortex: 31 nTPM
  • pituitary gland: 30 nTPM
  • pancreas: 27 nTPM

Single-cell type

  • late spermatids: 487 nCPM
  • early spermatids: 53 nCPM
  • late primary spermatocytes: 32 nCPM
  • pancreatic islet cells: 32 nCPM
  • megakaryocytes: 25 nCPM
  • neuroendocrine cells: 20 nCPM

Immune cell

  • memory B-cell: 11 nTPM
  • naive B-cell: 8.3 nTPM
  • MAIT T-cell: 7.9 nTPM
  • T-reg: 6.3 nTPM
  • memory CD4 T-cell: 5.9 nTPM
  • memory CD8 T-cell: 5.4 nTPM

Brain region

  • cerebellum: 39 nTPM
  • cerebral cortex: 33 nTPM
  • hippocampal formation: 30 nTPM
  • pons: 27 nTPM
  • thalamus: 26 nTPM
  • amygdala: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.02
gnomAD pLI
0.01
gnomAD missense Z
1.69
DepMap mean gene effect
-0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PARD6A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PARD6A as an antibody target. Whether an autoantibody or antibody against PARD6A could matter depends on whether native PARD6A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PARD6A is annotated at the cell surface, where native PARD6A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PARD6A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PARD6A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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