Seroatlas · Human Serome Atlas

IGBP1

Immunoglobulin-binding protein 1

Also known as: alpha4, IBP1, IGBP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P78318
Gene: IGBP1
Ensembl: ENSG00000089289
Chromosome: X
Canonical length: 339 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Microtubules,Cytokinetic bridge,Primary cilium,Basal body

OverviewNCBI Gene

The proliferation and differentiation of B cells is dependent upon a B-cell antigen receptor (BCR) complex. Binding of antigens to specific B-cell receptors results in a tyrosine phosphorylation reaction through the BCR complex and leads to multiple signal transduction pathways. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

339 residues, UniProt reviewed canonical sequence.

>P78318|IGBP1
     1  MAAEDELQLP RLPELFETGR QLLDEVEVAT EPAGSRIVQE KVFKGLDLLE KAAEMLSQLD
    61  LFSRNEDLEE IASTDLKYLL VPAFQGALTM KQVNPSKRLD HLQRAREHFI NYLTQCHCYH
   121  VAEFELPKTM NNSAENHTAN SSMAYPSLVA MASQRQAKIQ RYKQKKELEH RLSAMKSAVE
   181  SGQADDERVR EYYLLHLQRW IDISLEEIES IDQEIKILRE RDSSREASTS NSSRQERPPV
   241  KPFILTRNMA QAKVFGAGYP SLPTMTVSDW YEQHRKYGAL PDQGIAKAAP EEFRKAAQQQ
   301  EEQEEKEEED DEQTLHRARE WDDWKDTHPR GYGNRQNMG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGBP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 118 nTPM

Expression across tissuesHPA

Tissue

ovary: 118 nTPM
skeletal muscle: 112 nTPM
pancreas: 111 nTPM
tongue: 93 nTPM
fallopian tube: 69 nTPM
stomach: 66 nTPM

Single-cell type

enterocytes: 341 nCPM
esophageal apical cells: 338 nCPM
pancreatic acinar cells: 226 nCPM
decidual stromal cells: 222 nCPM
extravillous trophoblasts: 209 nCPM
ovarian stromal cells: 186 nCPM

Immune cell

T-reg: 75 nTPM
naive CD4 T-cell: 54 nTPM
basophil: 51 nTPM
myeloid DC: 51 nTPM
memory B-cell: 51 nTPM
naive CD8 T-cell: 49 nTPM

Brain region

white matter: 36 nTPM
spinal cord: 35 nTPM
hypothalamus: 31 nTPM
medulla oblongata: 31 nTPM
cerebellum: 31 nTPM
pons: 31 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IGBP1.

Disease | AllUniProt

Conditions IGBP1 is implicated in, by any mechanism.

Intellectual developmental disorder, X-linked, syndromic 28 (MRXS28) MIM:300472

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 89 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Corpus callosum agenesis-intellectual disability-coloboma-micrognathia syndrome

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.24
gnomAD pLI: 0.98
gnomAD missense Z: 1.3
DepMap mean gene effect: -1.46
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IGBP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGBP1 as an antibody target. Whether an autoantibody or antibody against IGBP1 could matter depends on whether native IGBP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGBP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IGBP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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