Seroatlas · Human Serome Atlas

CDC20

Cell division cycle protein 20 homolog

Also known as: CDC20_HUMAN, CDC20A, p55CDC

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q12834
Gene
CDC20
Ensembl
ENSG00000117399
Chromosome
1
Canonical length
499 aa
Protein class
Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Transporters
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell cycle. It is required for two microtubule-dependent processes, nuclear movement prior to anaphase and chromosome separation. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

499 residues, UniProt reviewed canonical sequence.

>Q12834|CDC20
     1  MAQFAFESDL HSLLQLDAPI PNAPPARWQR KAKEAAGPAP SPMRAANRSH SAGRTPGRTP
    61  GKSSSKVQTT PSKPGGDRYI PHRSAAQMEV ASFLLSKENQ PENSQTPTKK EHQKAWALNL
   121  NGFDVEEAKI LRLSGKPQNA PEGYQNRLKV LYSQKATPGS SRKTCRYIPS LPDRILDAPE
   181  IRNDYYLNLV DWSSGNVLAV ALDNSVYLWS ASSGDILQLL QMEQPGEYIS SVAWIKEGNY
   241  LAVGTSSAEV QLWDVQQQKR LRNMTSHSAR VGSLSWNSYI LSSGSRSGHI HHHDVRVAEH
   301  HVATLSGHSQ EVCGLRWAPD GRHLASGGND NLVNVWPSAP GEGGWVPLQT FTQHQGAVKA
   361  VAWCPWQSNV LATGGGTSDR HIRIWNVCSG ACLSAVDAHS QVCSILWSPH YKELISGHGF
   421  AQNQLVIWKY PTMAKVAELK GHTSRVLSLT MSPDGATVAS AAADETLRLW RCFELDPARR
   481  REREKASAAK SSLIHQGIR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDC20 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
51 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 51 nTPM
  • thymus: 49 nTPM
  • tonsil: 48 nTPM
  • testis: 47 nTPM
  • lymph node: 30 nTPM
  • esophagus: 27 nTPM

Single-cell type

  • late primary spermatocytes: 259 nCPM
  • extravillous trophoblasts: 148 nCPM
  • esophageal basal cells: 131 nCPM
  • early spermatids: 121 nCPM
  • migrating cytotrophoblasts: 120 nCPM
  • erythrocyte progenitors: 117 nCPM

Immune cell

  • T-reg: 12 nTPM
  • NK-cell: 9.6 nTPM
  • memory B-cell: 4.2 nTPM
  • memory CD8 T-cell: 3.5 nTPM
  • memory CD4 T-cell: 3.2 nTPM
  • total PBMC: 2.8 nTPM

Brain region

  • thalamus: 4 nTPM
  • medulla oblongata: 2.7 nTPM
  • white matter: 2.6 nTPM
  • pons: 2.2 nTPM
  • basal ganglia: 2 nTPM
  • hypothalamus: 2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CDC20.

Disease | AllUniProt

Conditions CDC20 is implicated in, by any mechanism.

  • Oocyte/zygote/embryo maturation arrest 14 (OZEMA14) MIM:620276

Disease | GeneticClinVar

12 pathogenic / likely-pathogenic of 84 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.84
gnomAD pLI
0
gnomAD missense Z
1.83
DepMap mean gene effect
-2.03
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CDC20 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDC20 as an antibody target. Whether an autoantibody or antibody against CDC20 could matter depends on whether native CDC20 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDC20 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDC20 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CDC20. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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