Seroatlas · Human Serome Atlas

PPP2CA

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

Also known as: PP2AA_HUMAN, PP2AC, PP2Calpha

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P67775
Gene
PPP2CA
Ensembl
ENSG00000113575
Chromosome
5
Canonical length
309 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

309 residues, UniProt reviewed canonical sequence.

>P67775|PPP2CA
     1  MDEKVFTKEL DQWIEQLNEC KQLSESQVKS LCEKAKEILT KESNVQEVRC PVTVCGDVHG
    61  QFHDLMELFR IGGKSPDTNY LFMGDYVDRG YYSVETVTLL VALKVRYRER ITILRGNHES
   121  RQITQVYGFY DECLRKYGNA NVWKYFTDLF DYLPLTALVD GQIFCLHGGL SPSIDTLDHI
   181  RALDRLQEVP HEGPMCDLLW SDPDDRGGWG ISPRGAGYTF GQDISETFNH ANGLTLVSRA
   241  HQLVMEGYNW CHDRNVVTIF SAPNYCYRCG NQAAIMELDD TLKYSFLQFD PAPRRGEPHV
   301  TRRTPDYFL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPP2CA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.23
Highest tissue expression
187 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 187 nTPM
  • heart muscle: 156 nTPM
  • thymus: 138 nTPM
  • parathyroid gland: 128 nTPM
  • tonsil: 127 nTPM
  • cerebral cortex: 116 nTPM

Single-cell type

  • tuft cells: 12 nCPM
  • hepatic stellate cells: 6.5 nCPM
  • megakaryocytes: 6.2 nCPM
  • ocular epithelial cells: 5.2 nCPM
  • erythrocyte progenitors: 4.8 nCPM
  • megakaryocyte progenitors: 4.5 nCPM

Immune cell

  • total PBMC: 158 nTPM
  • myeloid DC: 130 nTPM
  • eosinophil: 125 nTPM
  • neutrophil: 122 nTPM
  • NK-cell: 120 nTPM
  • T-reg: 119 nTPM

Brain region

  • cerebral cortex: 140 nTPM
  • cerebellum: 122 nTPM
  • hypothalamus: 115 nTPM
  • white matter: 113 nTPM
  • basal ganglia: 111 nTPM
  • spinal cord: 110 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PPP2CA.

Disease | AllUniProt

Conditions PPP2CA is implicated in, by any mechanism.

Disease | GeneticClinVar

42 pathogenic / likely-pathogenic of 277 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.26
gnomAD pLI
0.99
gnomAD missense Z
4.15
DepMap mean gene effect
-0.96
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PPP2CA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPP2CA as an antibody target. Whether an autoantibody or antibody against PPP2CA could matter depends on whether native PPP2CA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPP2CA is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPP2CA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PPP2CA. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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