Seroatlas · Human Serome Atlas

FBXW5

F-box/WD repeat-containing protein 5

Also known as: DKFZP434B205, Fbw5, FBXW5_HUMAN, MGC20962

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q969U6
Gene: FBXW5
Ensembl: ENSG00000159069
Chromosome: 9
Canonical length: 566 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

566 residues, UniProt reviewed canonical sequence.

>Q969U6|FBXW5
     1  MDEGGTPLLP DSLVYQIFLS LGPADVLAAG LVCRQWQAVS RDEFLWREQF YRYYQVARDV
    61  PRHPAAMSWY EEFQRLYDTV PCVEVQTLRE HTDQVLHLSF SHSGYQFASC SKDCTVKIWS
   121  NDLTISLLHS ADMRPYNWSY TQFSQFNKDD SLLLASGVFL GPHNSSSGEI AVISLDSFAL
   181  LSRVRNKPYD VFGCWLTETS LISGNLHRIG DITSCSVLWL NNAFQDVESE NVNVVKRLFK
   241  IQNLNASTVR TVMVADCSRF DSPDLLLEAG DPATSPCRIF DLGSDNEEVV AGPAPAHAKE
   301  GLRHFLDRVL EGRAQPQLSE RMLETKVAEL LAQGHTKPPE RSATGAKSKY LIFTTGCLTY
   361  SPHQIGIKQI LPHQMTTAGP VLGEGRGSDA FFDALDHVID IHGHIIGMGL SPDNRYLYVN
   421  SRAWPNGAVV ADPMQPPPIA EEIDLLVFDL KTMREVRRAL RAHRAYTPND ECFFIFLDVS
   481  RDFVASGAED RHGYIWDRHY NICLARLRHE DVVNSVVFSP QEQELLLTAS DDATIKAWRS
   541  PRTMRVLQAP RPRPRTFFSW LASQRR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FBXW5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 220 nTPM

Expression across tissuesHPA

Tissue

testis: 220 nTPM
skeletal muscle: 161 nTPM
blood vessel: 118 nTPM
liver: 110 nTPM
heart muscle: 96 nTPM
colon: 63 nTPM

Single-cell type

late spermatids: 3,413 nCPM
late primary spermatocytes: 640 nCPM
early spermatids: 576 nCPM
enterocytes: 397 nCPM
esophageal apical cells: 363 nCPM
colonocytes: 266 nCPM

Immune cell

plasmacytoid DC: 99 nTPM
gdT-cell: 98 nTPM
T-reg: 97 nTPM
eosinophil: 88 nTPM
memory CD8 T-cell: 83 nTPM
MAIT T-cell: 75 nTPM

Brain region

hippocampal formation: 65 nTPM
thalamus: 61 nTPM
cerebral cortex: 58 nTPM
pons: 52 nTPM
midbrain: 50 nTPM
amygdala: 50 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.53
gnomAD pLI: 0
gnomAD missense Z: -1.9
DepMap mean gene effect: -0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

protein kinase binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

WD40 repeat
F-box domain
WD40/YVTN repeat-like-containing domain superfamily
F-box-like domain superfamily
WD40-repeat-containing domain superfamily
WD domain, G-beta repeat
F-box-like
F-box/WD repeat-containing protein 5

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FBXW5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FBXW5 as an antibody target. Whether an autoantibody or antibody against FBXW5 could matter depends on whether native FBXW5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FBXW5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FBXW5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...