Seroatlas · Human Serome Atlas

CAPZB

F-actin-capping protein subunit beta

Also known as: CAPZB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P47756
Gene
CAPZB
Ensembl
ENSG00000077549
Chromosome
1
Canonical length
272 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Vesicles,Cytosol

OverviewNCBI Gene

This gene encodes the beta subunit of the barbed-end actin binding protein, which belongs to the F-actin capping protein family. The capping protein is a heterodimeric actin capping protein that blocks actin filament assembly and disassembly at the fast growing (barbed) filament ends and functions in regulating actin filament dynamics as well as in stabilizing actin filament lengths in muscle and nonmuscle cells. A pseudogene of this gene is located on the long arm of chromosome 2. Multiple alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

272 residues, UniProt reviewed canonical sequence.

>P47756|CAPZB
     1  MSDQQLDCAL DLMRRLPPQQ IEKNLSDLID LVPSLCEDLL SSVDQPLKIA RDKVVGKDYL
    61  LCDYNRDGDS YRSPWSNKYD PPLEDGAMPS ARLRKLEVEA NNAFDQYRDL YFEGGVSSVY
   121  LWDLDHGFAG VILIKKAGDG SKKIKGCWDS IHVVEVQEKS SGRTAHYKLT STVMLWLQTN
   181  KSGSGTMNLG GSLTRQMEKD ETVSDCSPHI ANIGRLVEDM ENKIRSTLNE IYFGKTKDIV
   241  NGLRSVQTFA DKSKQEALKN DLVEALKRKQ QC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CAPZB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
276 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 276 nTPM
  • blood vessel: 258 nTPM
  • tonsil: 255 nTPM
  • colon: 246 nTPM
  • smooth muscle: 223 nTPM
  • thymus: 221 nTPM

Single-cell type

  • late spermatids: 6,076 nCPM
  • hofbauer cells: 1,600 nCPM
  • early spermatids: 1,378 nCPM
  • esophageal apical cells: 1,196 nCPM
  • neutrophils: 1,100 nCPM
  • megakaryocytes: 1,014 nCPM

Immune cell

  • eosinophil: 1,079 nTPM
  • non-classical monocyte: 706 nTPM
  • total PBMC: 596 nTPM
  • neutrophil: 578 nTPM
  • intermediate monocyte: 542 nTPM
  • basophil: 458 nTPM

Brain region

  • white matter: 141 nTPM
  • hippocampal formation: 132 nTPM
  • thalamus: 128 nTPM
  • medulla oblongata: 121 nTPM
  • hypothalamus: 113 nTPM
  • pons: 112 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.38
gnomAD pLI
0.91
gnomAD missense Z
2.83
DepMap mean gene effect
-1.05
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CAPZB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CAPZB as an antibody target. Whether an autoantibody or antibody against CAPZB could matter depends on whether native CAPZB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CAPZB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CAPZB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CAPZB. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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