Seroatlas · Human Serome Atlas

PDCL3

Phosducin-like protein 3

Also known as: PDCL3_HUMAN, VIAF1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H2J4
Gene: PDCL3
Ensembl: ENSG00000115539
Chromosome: 2
Canonical length: 239 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a member of the phosducin-like protein family and is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin. Members of the phosducin-like protein family have been shown to bind to the beta-gamma subunits of G proteins. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

239 residues, UniProt reviewed canonical sequence.

>Q9H2J4|PDCL3
     1  MQDPNADTEW NDILRKKGIL PPKESLKELE EEAEEEQRIL QQSVVKTYED MTLEELEDHE
    61  DEFNEEDERA IEMYRRRRLA EWKATKLKNK FGEVLEISGK DYVQEVTKAG EGLWVILHLY
   121  KQGIPLCALI NQHLSGLARK FPDVKFIKAI STTCIPNYPD RNLPTIFVYL EGDIKAQFIG
   181  PLVFGGMNLT RDELEWKLSE SGAIMTDLEE NPKKPIEDVL LSSVRRSVLM KRDSDSEGD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PDCL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 59 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 59 nTPM
urinary bladder: 43 nTPM
blood vessel: 38 nTPM
smooth muscle: 36 nTPM
epididymis: 35 nTPM
skin: 35 nTPM

Single-cell type

oocytes: 143 nCPM
undifferentiated spermatogonia: 85 nCPM
thymic myoid cells: 68 nCPM
cytotrophoblasts: 68 nCPM
esophageal suprabasal cells: 63 nCPM
smooth muscle cells: 60 nCPM

Immune cell

non-classical monocyte: 162 nTPM
intermediate monocyte: 124 nTPM
myeloid DC: 115 nTPM
T-reg: 114 nTPM
naive CD4 T-cell: 98 nTPM
memory CD4 T-cell: 95 nTPM

Brain region

midbrain: 28 nTPM
thalamus: 23 nTPM
medulla oblongata: 22 nTPM
white matter: 22 nTPM
pons: 21 nTPM
cerebellum: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.35
gnomAD pLI: 0
gnomAD missense Z: -0.45
DepMap mean gene effect: -0.38
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PDCL3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PDCL3 as an antibody target. Whether an autoantibody or antibody against PDCL3 could matter depends on whether native PDCL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PDCL3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PDCL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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