Seroatlas · Human Serome Atlas

DDB2

DNA damage-binding protein 2

Also known as: DDB2_HUMAN, DDBB, FLJ34321, UV-DDB2, XPE

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q92466
Gene
DDB2
Ensembl
ENSG00000134574
Chromosome
11
Canonical length
427 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cell Junctions

OverviewNCBI Gene

This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Canonical amino-acid sequenceUniProt

427 residues, UniProt reviewed canonical sequence.

>Q92466|DDB2
     1  MAPKKRPETQ KTSEIVLRPR NKRSRSPLEL EPEAKKLCAK GSGPSRRCDS DCLWVGLAGP
    61  QILPPCRSIV RTLHQHKLGR ASWPSVQQGL QQSFLHTLDS YRILQKAAPF DRRATSLAWH
   121  PTHPSTVAVG SKGGDIMLWN FGIKDKPTFI KGIGAGGSIT GLKFNPLNTN QFYASSMEGT
   181  TRLQDFKGNI LRVFASSDTI NIWFCSLDVS ASSRMVVTGD NVGNVILLNM DGKELWNLRM
   241  HKKKVTHVAL NPCCDWFLAT ASVDQTVKIW DLRQVRGKAS FLYSLPHRHP VNAACFSPDG
   301  ARLLTTDQKS EIRVYSASQW DCPLGLIPHP HRHFQHLTPI KAAWHPRYNL IVVGRYPDPN
   361  FKSCTPYELR TIDVFDGNSG KMMCQLYDPE SSGISSLNEF NPMGDTLASA MGYHILIWSQ
   421  EEARTRK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DDB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
44 nTPM

Expression across tissuesHPA

Tissue

  • skin: 44 nTPM
  • liver: 25 nTPM
  • esophagus: 23 nTPM
  • thymus: 22 nTPM
  • adrenal gland: 22 nTPM
  • blood vessel: 21 nTPM

Single-cell type

  • adrenal cortex cells: 121 nCPM
  • esophageal basal cells: 96 nCPM
  • respiratory basal cells: 66 nCPM
  • basal prostatic cells: 65 nCPM
  • monocyte progenitors: 64 nCPM
  • microglia: 63 nCPM

Immune cell

  • T-reg: 48 nTPM
  • eosinophil: 20 nTPM
  • memory CD4 T-cell: 20 nTPM
  • gdT-cell: 19 nTPM
  • MAIT T-cell: 19 nTPM
  • memory CD8 T-cell: 19 nTPM

Brain region

  • white matter: 5.7 nTPM
  • cerebral cortex: 5.6 nTPM
  • medulla oblongata: 5.4 nTPM
  • choroid plexus: 5.2 nTPM
  • cerebellum: 5.1 nTPM
  • pons: 5.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DDB2.

Disease | AllUniProt

Conditions DDB2 is implicated in, by any mechanism.

  • Xeroderma pigmentosum complementation group E (XP-E) MIM:278740

Disease | GeneticClinVar

15 pathogenic / likely-pathogenic of 176 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Xeroderma pigmentosum, group E

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.85
gnomAD pLI
0
gnomAD missense Z
1.22
DepMap mean gene effect
-0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DDB2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DDB2 as an antibody target. Whether an autoantibody or antibody against DDB2 could matter depends on whether native DDB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DDB2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DDB2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DDB2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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