Seroatlas · Human Serome Atlas

PDCL

Phosducin-like protein

Also known as: DKFZp564M1863, PhLP, PHLP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q13371
Gene: PDCL
Ensembl: ENSG00000136940
Chromosome: 9
Canonical length: 301 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Phosducin-like protein is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin, a phosphoprotein expressed in retina and pineal gland. Both phosducin-like protein and phosphoducin have been shown to regulate G-protein signaling by binding to the beta-gamma subunits of G proteins. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

301 residues, UniProt reviewed canonical sequence.

>Q13371|PDCL
     1  MTTLDDKLLG EKLQYYYSSS EDEDSDHEDK DRGRCAPASS SVPAEAELAG EGISVNTGPK
    61  GVINDWRRFK QLETEQREEQ CREMERLIKK LSMTCRSHLD EEEEQQKQKD LQEKISGKMT
   121  LKEFAIMNED QDDEEFLQQY RKQRMEEMRQ QLHKGPQFKQ VFEISSGEGF LDMIDKEQKS
   181  IVIMVHIYED GIPGTEAMNG CMICLAAEYP AVKFCKVKSS VIGASSQFTR NALPALLIYK
   241  GGELIGNFVR VTDQLGDDFF AVDLEAFLQE FGLLPEKEVL VLTSVRNSAT CHSEDSDLEI
   301  D

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PDCL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 18 nTPM
placenta: 13 nTPM
endometrium: 12 nTPM
lung: 12 nTPM
lymph node: 12 nTPM
thymus: 12 nTPM

Single-cell type

megakaryocytes: 80 nCPM
platelets: 57 nCPM
mast cells: 51 nCPM
lymphatic endothelial cells: 45 nCPM
esophageal apical cells: 44 nCPM
endometrial luminal cells: 43 nCPM

Immune cell

T-reg: 31 nTPM
basophil: 31 nTPM
eosinophil: 24 nTPM
non-classical monocyte: 22 nTPM
NK-cell: 20 nTPM
naive CD4 T-cell: 19 nTPM

Brain region

white matter: 26 nTPM
hypothalamus: 24 nTPM
basal ganglia: 24 nTPM
pons: 24 nTPM
medulla oblongata: 24 nTPM
cerebellum: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.62
gnomAD pLI: 0.3
gnomAD missense Z: 1.12
DepMap mean gene effect: -0.29
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cell projection organization
positive regulation of smoothened signaling pathway
regulation of G protein-coupled receptor signaling pathway
signal transduction
visual perception
heterotrimeric G-protein complex assembly

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PDCL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PDCL as an antibody target. Whether an autoantibody or antibody against PDCL could matter depends on whether native PDCL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PDCL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PDCL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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