Seroatlas · Human Serome Atlas

PACRG

Parkin coregulated gene protein

Also known as: FLJ32724, Glup, HAK005771, PACRG_HUMAN, PARK2CRG

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96M98
Gene: PACRG
Ensembl: ENSG00000112530
Chromosome: 6
Canonical length: 296 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Mitochondria,Mid piece,Principal piece,End piece

OverviewNCBI Gene

This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

296 residues, UniProt reviewed canonical sequence.

>Q96M98|PACRG
     1  MVAEKETLSL NKCPDKMPKR TKLLAQQPLP VHQPHSLVSE GFTVKAMMKN SVVRGPPAAG
    61  AFKERPTKPT AFRKFYERGD FPIALEHDSK GNKIAWKVEI EKLDYHHYLP LFFDGLCEMT
   121  FPYEFFARQG IHDMLEHGGN KILPVLPQLI IPIKNALNLR NRQVICVTLK VLQHLVVSAE
   181  MVGKALVPYY RQILPVLNIF KNMNGSYSLP RLECSGAIMA RCNLDHLGSS DPPTSASQVA
   241  EIIVNSGDGI DYSQQKRENI GDLIQETLEA FERYGGENAF INIKYVVPTY ESCLLN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PACRG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 29 nTPM
testis: 23 nTPM
pituitary gland: 20 nTPM
choroid plexus: 14 nTPM
basal ganglia: 13 nTPM
hypothalamus: 13 nTPM

Single-cell type

renal collecting duct intercalated cells: 1,764 nCPM
respiratory ciliated cells: 1,762 nCPM
ependymal cells: 1,418 nCPM
epididymal clear cells: 1,202 nCPM
somatotrophs: 1,091 nCPM
thyrotrophs: 1,032 nCPM

Immune cell

neutrophil: 2.4 nTPM
basophil: 2.3 nTPM
naive CD4 T-cell: 1.3 nTPM
memory CD4 T-cell: 1.1 nTPM
classical monocyte: 0.7 nTPM
eosinophil: 0.7 nTPM

Brain region

white matter: 62 nTPM
medulla oblongata: 46 nTPM
midbrain: 46 nTPM
basal ganglia: 44 nTPM
cerebral cortex: 42 nTPM
hypothalamus: 40 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.24
gnomAD pLI: 0
gnomAD missense Z: 0.88
DepMap mean gene effect: 0.12
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PACRG in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PACRG as an antibody target. Whether an autoantibody or antibody against PACRG could matter depends on whether native PACRG is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PACRG is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PACRG as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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