Seroatlas · Human Serome Atlas

PPP4C

Serine/threonine-protein phosphatase 4 catalytic subunit

Also known as: PP4, PP4C_HUMAN, PPX

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P60510
Gene: PPP4C
Ensembl: ENSG00000149923
Chromosome: 16
Canonical length: 307 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

Enables protein serine/threonine phosphatase activity. Involved in regulation of double-strand break repair via homologous recombination. Located in several cellular components, including chromatin; cytosol; and nucleoplasm. Part of protein phosphatase 4 complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

307 residues, UniProt reviewed canonical sequence.

>P60510|PPP4C
     1  MAEISDLDRQ IEQLRRCELI KESEVKALCA KAREILVEES NVQRVDSPVT VCGDIHGQFY
    61  DLKELFRVGG DVPETNYLFM GDFVDRGFYS VETFLLLLAL KVRYPDRITL IRGNHESRQI
   121  TQVYGFYDEC LRKYGSVTVW RYCTEIFDYL SLSAIIDGKI FCVHGGLSPS IQTLDQIRTI
   181  DRKQEVPHDG PMCDLLWSDP EDTTGWGVSP RGAGYLFGSD VVAQFNAAND IDMICRAHQL
   241  VMEGYKWHFN ETVLTVWSAP NYCYRCGNVA AILELDEHLQ KDFIIFEAAP QETRGIPSKK
   301  PVADYFL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPP4C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.22
Highest tissue expression: 85 nTPM

Expression across tissuesHPA

Tissue

esophagus: 85 nTPM
liver: 80 nTPM
testis: 63 nTPM
spleen: 60 nTPM
tonsil: 60 nTPM
bone marrow: 60 nTPM

Single-cell type

esophageal apical cells: 678 nCPM
syncytiotrophoblasts: 497 nCPM
extravillous trophoblasts: 417 nCPM
migrating cytotrophoblasts: 367 nCPM
cytotrophoblasts: 359 nCPM
oocytes: 341 nCPM

Immune cell

eosinophil: 237 nTPM
neutrophil: 216 nTPM
myeloid DC: 116 nTPM
intermediate monocyte: 113 nTPM
classical monocyte: 104 nTPM
basophil: 101 nTPM

Brain region

choroid plexus: 37 nTPM
thalamus: 33 nTPM
white matter: 28 nTPM
hypothalamus: 26 nTPM
cerebellum: 26 nTPM
spinal cord: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.49
gnomAD pLI: 0.46
gnomAD missense Z: 3.55
DepMap mean gene effect: -1.15
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PPP4C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPP4C as an antibody target. Whether an autoantibody or antibody against PPP4C could matter depends on whether native PPP4C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPP4C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPP4C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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