Seroatlas · Human Serome Atlas

PPP6C

Serine/threonine-protein phosphatase 6 catalytic subunit

Also known as: PP6, PPP6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O00743
Gene: PPP6C
Ensembl: ENSG00000119414
Chromosome: 9
Canonical length: 305 aa
Protein class: Cancer-related genes, Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes the catalytic subunit of protein phosphatase, a component of a signaling pathway regulating cell cycle progression. Splice variants encoding different protein isoforms exist. The pseudogene of this gene is located on chromosome X. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

305 residues, UniProt reviewed canonical sequence.

>O00743|PPP6C
     1  MAPLDLDKYV EIARLCKYLP ENDLKRLCDY VCDLLLEESN VQPVSTPVTV CGDIHGQFYD
    61  LCELFRTGGQ VPDTNYIFMG DFVDRGYYSL ETFTYLLALK AKWPDRITLL RGNHESRQIT
   121  QVYGFYDECQ TKYGNANAWR YCTKVFDMLT VAALIDEQIL CVHGGLSPDI KTLDQIRTIE
   181  RNQEIPHKGA FCDLVWSDPE DVDTWAISPR GAGWLFGAKV TNEFVHINNL KLICRAHQLV
   241  HEGYKFMFDE KLVTVWSAPN YCYRCGNIAS IMVFKDVNTR EPKLFRAVPD SERVIPPRTT
   301  TPYFL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPP6C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.21
Highest tissue expression: 65 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 65 nTPM
tongue: 50 nTPM
bone marrow: 40 nTPM
thymus: 36 nTPM
tonsil: 34 nTPM
adipose tissue: 31 nTPM

Single-cell type

esophageal apical cells: 230 nCPM
neutrophils: 219 nCPM
late primary spermatocytes: 167 nCPM
neutrophil progenitors: 149 nCPM
myonuclei: 143 nCPM
syncytiotrophoblasts: 131 nCPM

Immune cell

basophil: 62 nTPM
neutrophil: 51 nTPM
T-reg: 39 nTPM
eosinophil: 36 nTPM
non-classical monocyte: 34 nTPM
intermediate monocyte: 29 nTPM

Brain region

white matter: 42 nTPM
basal ganglia: 33 nTPM
hypothalamus: 33 nTPM
cerebral cortex: 33 nTPM
cerebellum: 33 nTPM
spinal cord: 33 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.4
gnomAD pLI: 0.86
gnomAD missense Z: 2.58
DepMap mean gene effect: -0.4
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PPP6C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPP6C as an antibody target. Whether an autoantibody or antibody against PPP6C could matter depends on whether native PPP6C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPP6C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPP6C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...