Seroatlas · Human Serome Atlas

DNAAF10

Dynein axonemal assembly factor 10

Also known as: DAA10_HUMAN, FLJ31741, Monad, WDR92

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96MX6
Gene: DNAAF10
Ensembl: ENSG00000243667
Chromosome: 2
Canonical length: 357 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a protein with two WD40 repeat domains thought to be involved in an apoptosis via activation of caspase-3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

Canonical amino-acid sequenceUniProt

357 residues, UniProt reviewed canonical sequence.

>Q96MX6|DNAAF10
     1  MSAFEKPQII AHIQKGFNYT VFDCKWVPCS AKFVTMGNFA RGTGVIQLYE IQHGDLKLLR
    61  EIEKAKPIKC GTFGATSLQQ RYLATGDFGG NLHIWNLEAP EMPVYSVKGH KEIINAIDGI
   121  GGLGIGEGAP EIVTGSRDGT VKVWDPRQKD DPVANMEPVQ GENKRDCWTV AFGNAYNQEE
   181  RVVCAGYDNG DIKLFDLRNM ALRWETNIKN GVCSLEFDRK DISMNKLVAT SLEGKFHVFD
   241  MRTQHPTKGF ASVSEKAHKS TVWQVRHLPQ NRELFLTAGG AGGLHLWKYE YPIQRSKKDS
   301  EGIEMGVAGS VSLLQNVTLS TQPISSLDWS PDKRGLCVCS SFDQTVRVLI VTKLNKI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DNAAF10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.21
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

epididymis: 15 nTPM
skeletal muscle: 11 nTPM
fallopian tube: 10 nTPM
skin: 10 nTPM
lymph node: 9.1 nTPM
choroid plexus: 8.7 nTPM

Single-cell type

respiratory ciliated cells: 68 nCPM
fallopian tube ciliated cells: 61 nCPM
ependymal cells: 55 nCPM
epididymal efferent duct ciliated cells: 46 nCPM
adrenal medulla cells: 32 nCPM
endometrial ciliated cells: 31 nCPM

Immune cell

NK-cell: 6.3 nTPM
memory B-cell: 5.3 nTPM
naive CD8 T-cell: 5 nTPM
plasmacytoid DC: 5 nTPM
naive B-cell: 4.8 nTPM
MAIT T-cell: 4.2 nTPM

Brain region

choroid plexus: 27 nTPM
midbrain: 21 nTPM
cerebellum: 21 nTPM
basal ganglia: 19 nTPM
medulla oblongata: 18 nTPM
spinal cord: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.67
gnomAD pLI: 0.01
DepMap mean gene effect: -0.79
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ubiquitin binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DNAAF10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DNAAF10 as an antibody target. Whether an autoantibody or antibody against DNAAF10 could matter depends on whether native DNAAF10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DNAAF10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DNAAF10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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