Seroatlas · Human Serome Atlas

PPP2CB

Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

Also known as: PP2AB_HUMAN, PP2Abeta

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P62714
Gene
PPP2CB
Ensembl
ENSG00000104695
Chromosome
8
Canonical length
309 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes a beta isoform of the catalytic subunit. [provided by RefSeq, Mar 2010]

Canonical amino-acid sequenceUniProt

309 residues, UniProt reviewed canonical sequence.

>P62714|PPP2CB
     1  MDDKAFTKEL DQWVEQLNEC KQLNENQVRT LCEKAKEILT KESNVQEVRC PVTVCGDVHG
    61  QFHDLMELFR IGGKSPDTNY LFMGDYVDRG YYSVETVTLL VALKVRYPER ITILRGNHES
   121  RQITQVYGFY DECLRKYGNA NVWKYFTDLF DYLPLTALVD GQIFCLHGGL SPSIDTLDHI
   181  RALDRLQEVP HEGPMCDLLW SDPDDRGGWG ISPRGAGYTF GQDISETFNH ANGLTLVSRA
   241  HQLVMEGYNW CHDRNVVTIF SAPNYCYRCG NQAAIMELDD TLKYSFLQFD PAPRRGEPHV
   301  TRRTPDYFL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPP2CB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.22
Highest tissue expression
214 nTPM

Expression across tissuesHPA

Tissue

  • amygdala: 214 nTPM
  • midbrain: 196 nTPM
  • hippocampal formation: 195 nTPM
  • ovary: 190 nTPM
  • spinal cord: 187 nTPM
  • cerebral cortex: 186 nTPM

Single-cell type

  • peritubular myoid cells: 422 nCPM
  • alveolar cells type 1: 353 nCPM
  • esophageal apical cells: 307 nCPM
  • endometrial stromal cells: 304 nCPM
  • ovarian stromal cells: 267 nCPM
  • alveolar cells type 2: 251 nCPM

Immune cell

  • NK-cell: 3.8 nTPM
  • plasmacytoid DC: 3.8 nTPM
  • basophil: 3.4 nTPM
  • intermediate monocyte: 3.1 nTPM
  • memory B-cell: 2.9 nTPM
  • classical monocyte: 2.5 nTPM

Brain region

  • thalamus: 208 nTPM
  • medulla oblongata: 192 nTPM
  • white matter: 190 nTPM
  • spinal cord: 187 nTPM
  • basal ganglia: 183 nTPM
  • hypothalamus: 177 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.52
gnomAD pLI
0.34
gnomAD missense Z
3.11
DepMap mean gene effect
0.1
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PPP2CB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPP2CB as an antibody target. Whether an autoantibody or antibody against PPP2CB could matter depends on whether native PPP2CB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPP2CB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPP2CB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PPP2CB. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...