Seroatlas · Human Serome Atlas

LCOR

Ligand-dependent corepressor

Also known as: C10orf12, DKFZP564P1916, FLJ13022, FLJ38026, KIAA1795, LCOR_HUMAN, MLR2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96JN0
Gene: LCOR
Ensembl: ENSG00000196233
Chromosome: 10
Canonical length: 433 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box (Fernandes et al., 2003 [PubMed 12535528]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

433 residues, UniProt reviewed canonical sequence.

>Q96JN0|LCOR
     1  MQRMIQQFAA EYTSKNSSTQ DPSQPNSTKN QSLPKASPVT TSPTAATTQN PVLSKLLMAD
    61  QDSPLDLTVR KSQSEPSEQD GVLDLSTKKS PCAGSTSLSH SPGCSSTQGN GRPGRPSQYR
   121  PDGLRSGDGV PPRSLQDGTR EGFGHSTSLK VPLARSLQIS EELLSRNQLS TAASLGPSGL
   181  QNHGQHLILS REASWAKPHY EFNLSRMKFR GNGALSNISD LPFLAENSAF PKMALQAKQD
   241  GKKDVSHSSP VDLKIPQVRG MDLSWESRTG DQYSYSSLVM GSQTESALSK KLRAILPKQS
   301  RKSMLDAGPD SWGSDAEQST SGQPYPTSDQ EGDPGSKQPR KKRGRYRQYN SEILEEAISV
   361  VMSGKMSVSK AQSIYGIPHS TLEYKVKERL GTLKNPPKKK MKLMRSEGPD VSVKIELDPQ
   421  GEAAQSANES KNE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LCOR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.68
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 24 nTPM
retina: 15 nTPM
duodenum: 11 nTPM
small intestine: 10 nTPM
skeletal muscle: 8.6 nTPM
colon: 8.1 nTPM

Single-cell type

neutrophils: 650 nCPM
myonuclei: 536 nCPM
neutrophil progenitors: 459 nCPM
urothelial cells: 364 nCPM
oligodendrocytes: 327 nCPM
microglia: 310 nCPM

Immune cell

neutrophil: 17 nTPM
naive B-cell: 8.7 nTPM
eosinophil: 8.1 nTPM
gdT-cell: 5.9 nTPM
plasmacytoid DC: 5.4 nTPM
memory CD8 T-cell: 5.3 nTPM

Brain region

cerebellum: 78 nTPM
hypothalamus: 59 nTPM
white matter: 58 nTPM
thalamus: 43 nTPM
medulla oblongata: 42 nTPM
pons: 41 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.35
gnomAD pLI: 0.95
gnomAD missense Z: 1.12
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LCOR in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LCOR as an antibody target. Whether an autoantibody or antibody against LCOR could matter depends on whether native LCOR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LCOR is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LCOR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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