Seroatlas · Human Serome Atlas

NEDD1

Protein NEDD1

Also known as: GCP-WD, NEDD1_HUMAN, TUBGCP7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NHV4
Gene: NEDD1
Ensembl: ENSG00000139350
Chromosome: 12
Canonical length: 660 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Centrosome

OverviewNCBI Gene

Predicted to enable gamma-tubulin binding activity. Predicted to be involved in microtubule nucleation and mitotic cell cycle. Located in centrosome; cytosol; and nuclear lumen. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

660 residues, UniProt reviewed canonical sequence.

>Q8NHV4|NEDD1
     1  MQENLRFASS GDDIKIWDAS SMTLVDKFNP HTSPHGISSI CWSSNNNFLV TASSSGDKIV
    61  VSSCKCKPVP LLELAEGQKQ TCVNLNSTSM YLVSGGLNNT VNIWDLKSKR VHRSLKDHKD
   121  QVTCVTYNWN DCYIASGSLS GEIILHSVTT NLSSTPFGHG SNQSVRHLKY SLFKKSLLGS
   181  VSDNGIVTLW DVNSQSPYHN FDSVHKAPAS GICFSPVNEL LFVTIGLDKR IILYDTSSKK
   241  LVKTLVADTP LTAVDFMPDG ATLAIGSSRG KIYQYDLRML KSPVKTISAH KTSVQCIAFQ
   301  YSTVLTKSSL NKGCSNKPTT VNKRSVNVNA ASGGVQNSGI VREAPATSIA TVLPQPMTSA
   361  MGKGTVAVQE KAGLPRSINT DTLSKETDSG KNQDFSSFDD TGKSSLGDMF SPIRDDAVVN
   421  KGSDESIGKG DGFDFLPQLN SVFPPRKNPV TSSTSVLHSS PLNVFMGSPG KEENENRDLT
   481  AESKKIYMGK QESKDSFKQL AKLVTSGAES GNLNTSPSSN QTRNSEKFEK PENEIEAQLI
   541  CEPPINGSST PNPKIASSVT AGVASSLSEK IADSIGNNRQ NAPLTSIQIR FIQNMIQETL
   601  DDFREACHRD IVNLQVEMIK QFHMQLNEMH SLLERYSVNE GLVAEIERLR EENKRLRAHF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NEDD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 36 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 36 nTPM
tongue: 24 nTPM
testis: 22 nTPM
thymus: 21 nTPM
bone marrow: 14 nTPM
lymph node: 14 nTPM

Single-cell type

late primary spermatocytes: 254 nCPM
early spermatids: 236 nCPM
late spermatids: 131 nCPM
neutrophil progenitors: 116 nCPM
corticotrophs: 96 nCPM
monocyte progenitors: 76 nCPM

Immune cell

eosinophil: 26 nTPM
NK-cell: 20 nTPM
T-reg: 18 nTPM
MAIT T-cell: 16 nTPM
naive CD4 T-cell: 16 nTPM
memory CD4 T-cell: 15 nTPM

Brain region

choroid plexus: 16 nTPM
white matter: 13 nTPM
medulla oblongata: 11 nTPM
spinal cord: 9.8 nTPM
hypothalamus: 9.6 nTPM
midbrain: 9.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.42
gnomAD pLI: 0.42
gnomAD missense Z: 0.33
DepMap mean gene effect: -1.83
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

gamma-tubulin binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

WD40 repeat
WD40/YVTN repeat-like-containing domain superfamily
WD40 repeat, conserved site
WD40-repeat-containing domain superfamily
WD domain, G-beta repeat
NEDD1 Spindle Assembly Protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NEDD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NEDD1 as an antibody target. Whether an autoantibody or antibody against NEDD1 could matter depends on whether native NEDD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NEDD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NEDD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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