7 transmembrane receptor (Secretin family)
PF00002
Definition
This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs). They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognised. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97 ([swissprot:P48960]); calcium-independent receptors for latrotoxin (such as [swissprot:O94910]), and brain-specific angiogenesis inhibitors (such as [swissprot:O14514]) amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins (e.g. [swissprot:P83119]). Other than the typical seven-transmembrane region, characteristic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling PMID:11790261.
49 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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