Seroatlas · Human Serome Atlas

CALCRL

Calcitonin gene-related peptide type 1 receptor

Also known as: CALRL_HUMAN, CGRPR, CRLR

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q16602
Gene
CALCRL
Ensembl
ENSG00000064989
Chromosome
2
Canonical length
461 aa
Protein class
Disease related genes, FDA approved drug targets, G-protein coupled receptors, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Plasma membrane

OverviewNCBI Gene

Enables adrenomedullin binding activity; adrenomedullin receptor activity; and calcitonin gene-related peptide receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; cellular response to sucrose stimulus; and receptor internalization. Located in several cellular components, including endoplasmic reticulum; endosome; and lysosome. Part of CGRP receptor complex and adrenomedullin receptor complex. Implicated in hereditary lymphedema. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

461 residues, UniProt reviewed canonical sequence.

>Q16602|CALCRL
     1  MEKKCTLYFL VLLPFFMILV TAELEESPED SIQLGVTRNK IMTAQYECYQ KIMQDPIQQA
    61  EGVYCNRTWD GWLCWNDVAA GTESMQLCPD YFQDFDPSEK VTKICDQDGN WFRHPASNRT
   121  WTNYTQCNVN THEKVKTALN LFYLTIIGHG LSIASLLISL GIFFYFKSLS CQRITLHKNL
   181  FFSFVCNSVV TIIHLTAVAN NQALVATNPV SCKVSQFIHL YLMGCNYFWM LCEGIYLHTL
   241  IVVAVFAEKQ HLMWYYFLGW GFPLIPACIH AIARSLYYND NCWISSDTHL LYIIHGPICA
   301  ALLVNLFFLL NIVRVLITKL KVTHQAESNL YMKAVRATLI LVPLLGIEFV LIPWRPEGKI
   361  AEEVYDYIMH ILMHFQGLLV STIFCFFNGE VQAILRRNWN QYKIQFGNSF SNSEALRSAS
   421  YTVSTISDGP GYSHDCPSEH LNGKSIHDIE NVLLKPENLY N

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CALCRL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
72 nTPM

Expression across tissuesHPA

Tissue

  • lung: 72 nTPM
  • adipose tissue: 66 nTPM
  • thyroid gland: 26 nTPM
  • cervix: 26 nTPM
  • smooth muscle: 25 nTPM
  • ovary: 25 nTPM

Single-cell type

  • vascular endothelial cells: 949 nCPM
  • lymphatic endothelial cells: 598 nCPM
  • adipocytes: 380 nCPM
  • oligodendrocyte progenitor cells: 378 nCPM
  • bergmann glia: 333 nCPM
  • endometrial stromal cells: 222 nCPM

Immune cell

  • myeloid DC: 9.2 nTPM
  • classical monocyte: 2.6 nTPM
  • plasmacytoid DC: 2.6 nTPM
  • NK-cell: 1 nTPM
  • non-classical monocyte: 1 nTPM
  • total PBMC: 0.9 nTPM

Brain region

  • spinal cord: 34 nTPM
  • white matter: 32 nTPM
  • medulla oblongata: 24 nTPM
  • pons: 18 nTPM
  • cerebellum: 13 nTPM
  • midbrain: 11 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CALCRL.

Disease | AllUniProt

Conditions CALCRL is implicated in, by any mechanism.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 46 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Lymphatic malformation 8

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.3
gnomAD pLI
0.99
gnomAD missense Z
2.09
DepMap mean gene effect
0.1
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CALCRL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CALCRL as an antibody target. Whether an autoantibody or antibody against CALCRL could matter depends on whether native CALCRL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CALCRL is annotated at the cell surface, where native CALCRL is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CALCRL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CALCRL. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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