Seroatlas · Human Serome Atlas

ADGRG3

Adhesion G protein-coupled receptor G3

Also known as: AGRG3_HUMAN, GPR97, Pb99, PGR26

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86Y34
Gene: ADGRG3
Ensembl: ENSG00000182885
Chromosome: 16
Canonical length: 549 aa
Protein class: G-protein coupled receptors, Plasma proteins, Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable G protein-coupled receptor activity. Involved in G protein-coupled receptor signaling pathway and regulation of cell migration. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

549 residues, UniProt reviewed canonical sequence.

>Q86Y34|ADGRG3
     1  MATPRGLGAL LLLLLLPTSG QEKPTEGPRN TCLGSNNMYD IFNLNDKALC FTKCRQSGSD
    61  SCNVENLQRY WLNYEAHLMK EGLTQKVNTP FLKALVQNLS TNTAEDFYFS LEPSQVPRQV
   121  MKDEDKPPDR VRLPKSLFRS LPGNRSVVRL AVTILDIGPG TLFKGPRLGL GDGSGVLNNR
   181  LVGLSVGQMH VTKLAEPLEI VFSHQRPPPN MTLTCVFWDV TKGTTGDWSS EGCSTEVRPE
   241  GTVCCCDHLT FFALLLRPTL DQSTVHILTR ISQAGCGVSM IFLAFTIILY AFLRLSRERF
   301  KSEDAPKIHV ALGGSLFLLN LAFLVNVGSG SKGSDAACWA RGAVFHYFLL CAFTWMGLEA
   361  FHLYLLAVRV FNTYFGHYFL KLSLVGWGLP ALMVIGTGSA NSYGLYTIRD RENRTSLELC
   421  WFREGTTMYA LYITVHGYFL ITFLFGMVVL ALVVWKIFTL SRATAVKERG KNRKKVLTLL
   481  GLSSLVGVTW GLAIFTPLGL STVYIFALFN SLQGVFICCW FTILYLPSQS TTVSSSTARL
   541  DQAHSASQE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADGRG3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 139 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 139 nTPM
spleen: 35 nTPM
lung: 14 nTPM
appendix: 14 nTPM
adipose tissue: 7.9 nTPM
thyroid gland: 3.7 nTPM

Single-cell type

neutrophils: 1,722 nCPM
neutrophil progenitors: 444 nCPM
nk-cells: 64 nCPM
lymphatic endothelial cells: 56 nCPM
epididymal basal cells: 13 nCPM
platelets: 11 nCPM

Immune cell

neutrophil: 170 nTPM
eosinophil: 143 nTPM
basophil: 76 nTPM
NK-cell: 37 nTPM
total PBMC: 0.9 nTPM
non-classical monocyte: 0.1 nTPM

Brain region

cerebral cortex: 23 nTPM
pons: 4.2 nTPM
thalamus: 1 nTPM
choroid plexus: 0.6 nTPM
basal ganglia: 0.5 nTPM
medulla oblongata: 0.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.24
gnomAD pLI: 0
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

G protein-coupled receptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ADGRG3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ADGRG3 as an antibody target. Whether an autoantibody or antibody against ADGRG3 could matter depends on whether native ADGRG3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ADGRG3 is annotated at the cell surface, where native ADGRG3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ADGRG3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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