Seroatlas · Human Serome Atlas

VIPR1

Vasoactive intestinal polypeptide receptor 1

Also known as: HVR1, RDC1, VIPR1_HUMAN, VPAC1, VPAC1R

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P32241
Gene
VIPR1
Ensembl
ENSG00000114812
Chromosome
3
Canonical length
457 aa
Protein class
G-protein coupled receptors, Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Canonical amino-acid sequenceUniProt

457 residues, UniProt reviewed canonical sequence.

>P32241|VIPR1
     1  MRPPSPLPAR WLCVLAGALA WALGPAGGQA ARLQEECDYV QMIEVQHKQC LEEAQLENET
    61  IGCSKMWDNL TCWPATPRGQ VVVLACPLIF KLFSSIQGRN VSRSCTDEGW THLEPGPYPI
   121  ACGLDDKAAS LDEQQTMFYG SVKTGYTIGY GLSLATLLVA TAILSLFRKL HCTRNYIHMH
   181  LFISFILRAA AVFIKDLALF DSGESDQCSE GSVGCKAAMV FFQYCVMANF FWLLVEGLYL
   241  YTLLAVSFFS ERKYFWGYIL IGWGVPSTFT MVWTIARIHF EDYGCWDTIN SSLWWIIKGP
   301  ILTSILVNFI LFICIIRILL QKLRPPDIRK SDSSPYSRLA RSTLLLIPLF GVHYIMFAFF
   361  PDNFKPEVKM VFELVVGSFQ GFVVAILYCF LNGEVQAELR RKWRRWHLQG VLGWNPKYRH
   421  PSGGSNGATC STQVSMLTRV SPGARRSSSF QAEVSLV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VIPR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
124 nTPM

Expression across tissuesHPA

Tissue

  • lung: 124 nTPM
  • duodenum: 32 nTPM
  • liver: 32 nTPM
  • skin: 29 nTPM
  • small intestine: 28 nTPM
  • colon: 26 nTPM

Single-cell type

  • goblet cells: 100 nCPM
  • enterocytes: 99 nCPM
  • colonocytes: 94 nCPM
  • hepatic stellate cells: 65 nCPM
  • urothelial cells: 59 nCPM
  • breast lactating cells: 58 nCPM

Immune cell

  • naive CD4 T-cell: 2.7 nTPM
  • memory CD4 T-cell: 2.4 nTPM
  • myeloid DC: 2.1 nTPM
  • classical monocyte: 1.8 nTPM
  • intermediate monocyte: 1.5 nTPM
  • non-classical monocyte: 1.3 nTPM

Brain region

  • cerebral cortex: 25 nTPM
  • cerebellum: 20 nTPM
  • white matter: 17 nTPM
  • basal ganglia: 17 nTPM
  • amygdala: 9.8 nTPM
  • hippocampal formation: 9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about VIPR1.

Disease | ImmuneIEDB

Conditions an epitope on VIPR1 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.73
gnomAD pLI
0
gnomAD missense Z
0.07
DepMap mean gene effect
0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of VIPR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VIPR1 as an antibody target. Whether an autoantibody or antibody against VIPR1 could matter depends on whether native VIPR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VIPR1 is annotated at the cell surface, where native VIPR1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label VIPR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/VIPR1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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