Seroatlas · Human Serome Atlas

ADCYAP1R1

Pituitary adenylate cyclase-activating polypeptide type I receptor

Also known as: PAC1, PAC1R, PACAPR, PACR_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P41586
Gene
ADCYAP1R1
Ensembl
ENSG00000078549
Chromosome
7
Canonical length
468 aa
Protein class
G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Vesicles

OverviewNCBI Gene

This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

468 residues, UniProt reviewed canonical sequence.

>P41586|ADCYAP1R1
     1  MAGVVHVSLA ALLLLPMAPA MHSDCIFKKE QAMCLEKIQR ANELMGFNDS SPGCPGMWDN
    61  ITCWKPAHVG EMVLVSCPEL FRIFNPDQVW ETETIGESDF GDSNSLDLSD MGVVSRNCTE
   121  DGWSEPFPHY FDACGFDEYE SETGDQDYYY LSVKALYTVG YSTSLVTLTT AMVILCRFRK
   181  LHCTRNFIHM NLFVSFMLRA ISVFIKDWIL YAEQDSNHCF ISTVECKAVM VFFHYCVVSN
   241  YFWLFIEGLY LFTLLVETFF PERRYFYWYT IIGWGTPTVC VTVWATLRLY FDDTGCWDMN
   301  DSTALWWVIK GPVVGSIMVN FVLFIGIIVI LVQKLQSPDM GGNESSIYLR LARSTLLLIP
   361  LFGIHYTVFA FSPENVSKRE RLVFELGLGS FQGFVVAVLY CFLNGEVQAE IKRKWRSWKV
   421  NRYFAVDFKH RHPSLASSGV NGGTQLSILS KSSSQIRMSG LPADNLAT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADCYAP1R1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
76 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 76 nTPM
  • basal ganglia: 34 nTPM
  • fallopian tube: 29 nTPM
  • amygdala: 27 nTPM
  • midbrain: 22 nTPM
  • hippocampal formation: 13 nTPM

Single-cell type

  • pituicytes/fscs: 152 nCPM
  • adrenal medulla cells: 128 nCPM
  • astrocytes: 95 nCPM
  • pituitary stem cells: 53 nCPM
  • other brain neurons: 44 nCPM
  • brain inhibitory neurons: 36 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • thalamus: 341 nTPM
  • hypothalamus: 244 nTPM
  • midbrain: 237 nTPM
  • medulla oblongata: 224 nTPM
  • amygdala: 215 nTPM
  • pons: 211 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.87
gnomAD pLI
0
gnomAD missense Z
1.39
DepMap mean gene effect
0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ADCYAP1R1 as an antibody target. Whether an autoantibody or antibody against ADCYAP1R1 could matter depends on whether native ADCYAP1R1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ADCYAP1R1 is annotated at the cell surface, where native ADCYAP1R1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ADCYAP1R1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ADCYAP1R1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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