Seroatlas · Human Serome Atlas

SCTR

Secretin receptor

Also known as: SCTR_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P47872
Gene
SCTR
Ensembl
ENSG00000080293
Chromosome
2
Canonical length
440 aa
Protein class
FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins, Transporters

OverviewNCBI Gene

The protein encoded by this gene is a G protein-coupled receptor and belongs to the glucagon-VIP-secretin receptor family. It binds secretin which is the most potent regulator of pancreatic bicarbonate, electrolyte and volume secretion. Secretin and its receptor are suggested to be involved in pancreatic cancer and autism. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

440 residues, UniProt reviewed canonical sequence.

>P47872|SCTR
     1  MRPHLSPPLQ QLLLPVLLAC AAHSTGALPR LCDVLQVLWE EQDQCLQELS REQTGDLGTE
    61  QPVPGCEGMW DNISCWPSSV PGRMVEVECP RFLRMLTSRN GSLFRNCTQD GWSETFPRPN
   121  LACGVNVNDS SNEKRHSYLL KLKVMYTVGY SSSLVMLLVA LGILCAFRRL HCTRNYIHMH
   181  LFVSFILRAL SNFIKDAVLF SSDDVTYCDA HRAGCKLVMV LFQYCIMANY SWLLVEGLYL
   241  HTLLAISFFS ERKYLQGFVA FGWGSPAIFV ALWAIARHFL EDVGCWDINA NASIWWIIRG
   301  PVILSILINF ILFINILRIL MRKLRTQETR GNEVSHYKRL ARSTLLLIPL FGIHYIVFAF
   361  SPEDAMEIQL FFELALGSFQ GLVVAVLYCF LNGEVQLEVQ KKWQQWHLRE FPLHPVASFS
   421  NSTKASHLEQ SQGTCRTSII

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SCTR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
64 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 64 nTPM
  • duodenum: 25 nTPM
  • kidney: 11 nTPM
  • lung: 8.1 nTPM
  • stomach: 4.1 nTPM
  • small intestine: 3.5 nTPM

Single-cell type

  • pancreatic duct cells: 520 nCPM
  • loop of henle epithelial cells: 138 nCPM
  • adipocytes: 84 nCPM
  • alveolar cells type 2: 76 nCPM
  • gastric progenitor cells: 60 nCPM
  • epicardial cells: 57 nCPM

Immune cell

  • basophil: 0.6 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 2.2 nTPM
  • cerebral cortex: 2.2 nTPM
  • thalamus: 2.2 nTPM
  • pons: 2 nTPM
  • white matter: 1.9 nTPM
  • hippocampal formation: 1.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.14
gnomAD pLI
0
gnomAD missense Z
-0.02
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SCTR as an antibody target. Whether an autoantibody or antibody against SCTR could matter depends on whether native SCTR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SCTR is annotated at the cell surface, where native SCTR is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SCTR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SCTR. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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